Physicians' Attitudes towards and Reasons for Participation in the Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) Trial

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概要

• 論文の詳細を見る

• BACKGROUND: Physicians perception and attitudes towards a research topic and trial management could influence their participation in a randomized controlled trial. The objectives of this study were to determine the reasons for physicians participation in and attitudes towards the Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial.METHODS: CASE-Js main objective is to compare the effectiveness of an angiotensin II receptor antagonist (candesartan cilexetil) with that of a calcium channel blocker (amlodipine besilate) in terms of the incidence of cardiovascular events among high-risk hypertensive patients. We conducted a questionnaire survey among the physicians (n=512) participating in that trial to determine the reasons behind their participation and to elicit their reactions to the trial management.RESULTS: Eighty-eight percent of the 512 participating physicians responded to our survey. The main reasons for participation were clear objectives of the trial (85.1%), a simple protocol (61.1%), interest in finding out the inhibiting effects of the drugs on cardiac events (80.2%), and a well-organized support system (59.8%). As for negative factors, case registration and follow-up were considered cumbersome by 28.6% and 10.8%, respectively while 44.2% stated that support by the clinical research coordinators provided by the trial management authority was necessary for case screening, recruitment process, patient registration, and follow-up. Multivariate logistic regression analysis showed that participants who did not use a computer very regularly (odds ratio = 1.9, 95% confidence interval = 1.1-3.6) were more likely to consider the case registration and follow-up procedures as a cumbersome.CONCLUSION: The information generated by this study could be useful in designing future randomized controlled trials in Japan and abroad.J Epidemiol2005;15:38-40.

• 日本疫学会の論文
• 2005-03-01

著者

• MORIMOTO Shigeto

  Kanazawa Medical University

• Fukui Tsuguya

  St Luke's International Hospital

• Morimoto Shigeto

  金沢医科大学 高齢医学科

• MORITA Satoshi

  Department of Young Leaders' Program in Health Care Administration, Nagoya University Graduate Schoo

• SAKAMOTO Junichi

  Department of Young Leaders' Program in Health Care Administration, Nagoya University Graduate Schoo

• FUKUI Tsuguya

  Clinical Practice Evaluation and Research Center, St. Luke's Life Science Institute, St. Luke's Inte

• RAHMAN Mahbubur

  Clinical Practice Evaluation and Research Center, St. Luke's Life Science Institute, St. Luke's Inte

• RAHMAN Mahbubur

  Marshfield Epidemiology Research Center, Marshfield Clinic Research Foundation

• Rahman M

  Clinical Practice Evaluation And Research Center St. Luke's Life Science Institute St. Luke&apo

• Rahman Mahbubur

  Marshfield Epidemiology Research Center Marshfield Clinic Research Foundation

• Morita Satoshi

  Dep. Of Young Leaders' Program In Health Care Administration Nagoya Univ. Graduate School Of Me

• Sakamoto Junichi

  Department Of Epidemiological And Clinical Research Information Management Kyoto University Graduate

• Sakamoto J

  Aichi Prefectural Hospital Okazaki

• Rahman Mahbubur

  Clinical Practice Evaluation And Research Center St. Luke's Life Science Institute St. Luke&apo

• Morita Satoshi

  Department Of Epidemiological And Clinical Research Information Management Kyoto University Graduate

• Morita Satoshi

  Department Of Biostatistics And Epidemiology Yokohama City University Medical Center

• Sakamoto Junichi

  Department Of Agricultural Chemistry Kyushu University

• Morimoto Shigeto

  Department Of Epidemiological And Clinical Research Information Management Kyoto University Graduate

• Morimoto Shigeto

  Department Of Epidemiological And Clinical Research Information Management Kyoto University Graduate

• Morita Satoshi

  Department Of Biostatistics And Epidemiology Yokohama City University Graduate School Of Medicine

• MORITA Satoshi

  Department of Biostastics and Epidemiology, Yokohama City University Medical Center

• Fukui Tsuguya

  Clinical Practice Evaluation and Research Center, St. Luke's Life Science Institute, St. Luke's International Hospital

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