WEEKLY ASSESSMENT OF QUALITY OF LIFE IN PATIENTS WITH ADVANCED NON-SMALL-CELL LUNG CANCER DURING CHEMOTHERAPY IN A RANDOMIZED PHASE III TRIAL
スポンサーリンク
概要
- 論文の詳細を見る
This study investigated quality of life (QOL) in patients with advanced non-small-cell lung cancer in an early phase of chemotherapy in a randomized phase III trial. QOL assessments for four domains (functional, physical, mental, and psychosocial) and global QOL were self-administered every week during chemotherapy by 77 and 84 patients who received cisplatin plus irinotecan or cisplatin plus vindesine, respectively, with the schedules repeated every 4 weeks. Mean QOL scores at each week in the first and second courses of chemotherapy (weeks 1 to 8) were estimated for either treatment group and compared between groups using a longitudinal data analysis. The impact of non-hematological adverse events on QOL was examined using a general linear model. The maximum decrease in QOL scores (except for the psychosocial domain) was observed at weeks 1 and 5 for both groups, and recovery from the lapses was suggested before initiation of the next treatment course. There were statistically significant differences in QOL scores during the first course, favoring cisplatin plus vindesine for the physical domain. Nausea/vomiting was significantly related to deterioration in the three domains (except the psychosocial domain) and to global QOL for the first and second courses of either treatment group. These results comprehensively illustrate QOL in cancer patients during the early phase of chemotherapy and suggest that control of nausea/vomiting may be critical for the maintenance of QOL in cancer patients during chemotherapy.
著者
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Nagao Keiichi
Health Science Center Chiba University
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NIITANI Hisanobu
The Tokyo Cooperative Oncology Group
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Shibuya Masahiko
Division Of Cardiology Sakurabashi Watanabe Hospital
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Eguchi Kenji
Division Of Medical Oncology Department Of Internal Medicine Teikyo University School Of Medicine
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Sakamoto Junichi
Department Of Agricultural Chemistry Kyushu University
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Ohashi Yasuo
School Of Health Sciences And Nursing The University Of Tokyo
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Kobayashi Kunihiko
Department Of Agricultural Chemistry Faculty Of Agriclture Yamaguchi University
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MORITA Satoshi
Department of Biostastics and Epidemiology, Yokohama City University Medical Center
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MORITA Satoshi
Department of Epidemiology and Health Care Research, Kyoto University Graduate School of Medicine
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Yamaji Yasufumi
Department of Internal Medicine, Mitoyo General Hospital
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Matsumoto Taketoshi
Department of Respiratory Disease, Musashigaoka Hospital
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Sakamoto Junichi
Department of Epidemiological & Clinical Research Information Management, Kyoto University Graduate School of Medicine
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