Extract from Inflamed Skin of Rabbits Increases Enkephalin Concentrations in Cerebrospinal Fluid in Rats

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概要

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• A non-protein extract from inflamed skin of rabbits inoculated with vaccinia virus (EISRV) is widely employed to combat pain and allergic conditions. To investigate whether enkephalin could be involved in the analgesic activity of EISRV, we examined concentrations of Met^5-enkephalin and Leu^5-enkephalin in cerebrospinal fluid in male Wistar rats after intraperitoneal EISRV injection. EISRV increased both Met^5-enkephalin and Leu^5-enkephalin concentrations in a dose- and time-dependent manner. Although not statistically significant, there appeared to be a trend towards lowered activity of neutral endopeptidase (E. C. 3. 4. 24. 11), the major inactivator of enkephalins in the brain, in cerebrospinal fluid of rats treated with EISRV. There were no significant changes in thalamic mRNA levels of proenkephalin and prodynorphin after EISRV treatment. Thus, the antinociceptive effect of EISRV is possibly in part due to the accumulation of Met^5-enkephalin and Leu^5-enkephalin in cerebrospinal fluid, mediated through inhibition of neutral endopeptidase activity.

• 金沢医科大学の論文

著者

• MORIMOTO Shigeto

  Kanazawa Medical University

• Matsuzaki Masunori

  Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch

• Okuro Masashi

  Department Of Geriatric Medicine Kanazawa Medical University

• Morimoto Shigeto

  金沢医科大学 高齢医学科

• Morimoto Shigeto

  Department Of Geriatric Medicine Osaka University Medical School

• Kanda Tsugiyasu

  General Medicine Kanazawa Medical University

• MATSUMOTO Masayuki

  Department of Geriatric Medicine, Kanazawa Medical University

• TAKAHASHI Takashi

  General Medicine, Kanazawa Medical University

• NOMURA Kohji

  Department of Geriatric Medicine, Kanazawa Medical University

• Jackman Herbert

  Departments of Pharmacology and Anesthesiology, University of Illinois College of Medicine

• Erdos Ervin

  Departments of Pharmacology and Anesthesiology, University of Illinois College of Medicine

• Ohde Hironori

  Research Institute, Fujimoto Pharmaceutical Corp

• Liu Wei-Min

  Departments of Geriatric Medicine, Kanazawa Medical University

• Nomura Koji

  Department Of Geriatric Medicine Kanazawa Medical University

• Matsubara Mitsunobu

  Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine

• Miyahara Mitsuo

  The Second Department Of Internal Medicine Sapporo Medical College

• Erdos Ervin

  Departments Of Pharmacology And Anesthesiology University Of Illinois College Of Medicine

• Liu Wei-min

  Department Of Obstetrics And Gynecology Taipei Medical University Hospital And Taipei Medical Univer

• Liu Wei-min

  Departments Of Geriatric Medicine Kanazawa Medical University

• Nomura Kohji

  Department Of Biochemistry Tokyo Metropolitan Institute Of Gerontology

• Ohde Hironori

  Research Institute Fujimoto Pharmaceutical Corp

• Morimoto Shigeto

  Department Of Geriatric Medicine Graduate School Of Medicine Osaka University

• Matsuzaki Masunori

  Department Of Cardiovascular Medicine Yamaguchi University Graduate School Of Medicine

• Morita Satoshi

  Department Of Epidemiological And Clinical Research Information Management Kyoto University Graduate

• Jackman Herbert

  Departments Of Pharmacology And Anesthesiology University Of Illinois College Of Medicine

• Matsumoto Masayuki

  Department Of Geriatric Medicine Kanazawa Medical University

• Miyahara Mitsuo

  Dept. Of Intern. Med. (section 2) Sapporo Med. Coll.

• Mori Masaki

  Division Of Gene Therapy Science Osaka University

• Matsumoto Masayuki

  Department Of Electrical Engineering Faculty Of Engineering Toyo University

• Morimoto Shigeto

  Department Of Epidemiological And Clinical Research Information Management Kyoto University Graduate

• Morimoto Shigeto

  Department Of Epidemiological And Clinical Research Information Management Kyoto University Graduate

• Matsumoto Masayuki

  Department Of Cardiology Kyushu Kousei-nenkin Hospital

• Takahashi Takashi

  General Medicine Kanazawa Medical University

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