Impaired Expression of Cardiac Adiponectin in Leptin-Deficient Mice With Viral Myocarditis
スポンサーリンク
概要
- 論文の詳細を見る
A mouse model of encephalomyocarditis (EMC) virus-induced myocarditis was used to investigate the expression of adiponectin in damaged cardiomyocytes. We intraperitoneally injected EMC virus into leptin-deficient ob/ob (OB) mice and wild-type (WT) mice. OB mice were divided into two subgroups consisting of mice with no intervention and mice receiving leptin replacement starting simultaneously with viral inoculation. We determined differences in heart weight, cardiac histological score, numbers of infiltrating and apoptotic cells in the myocardium, expression levels of adiponectin and TNF-α mRNA in the heart, adiponectin immunoreactivity in myocytes, adiponectin and TNF-α concentrations in the heart, and immunoreactivity of adiponectin receptors in myocytes between OB mice and WT mice. There was significantly decreased adiponectin mRNA expression, immunoreactivity, and protein level in the heart, and reduced immunoreactivity of adiponectin receptor 1 in myocytes from OB mice on days 4 and 8 after viral inoculation as compared with those in WT mice, together with increased cardiac weight, severe inflammatory myocardial damage, and increased levels of cardiac TNF-α mRNA and protein. Replacement of leptin in OB mice inhibited the development of severe myocarditis through augmentation of adiponectin mRNA, immunoreactivity, and protein level, increased adiponectin receptor 1 immunoreactivity in myocytes, and suppressed levels of TNF-α mRNA and protein. These results suggest that impaired expression of cardiac adiponectin may contribute to the progression of viral myocarditis through enhanced expression of TNF-α under a leptin-deficient condition.
- インターナショナル・ハート・ジャーナル刊行会の論文
著者
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TAKAHASHI Takashi
Department of General Medicine, Kanazawa Medical University
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Kurabayashi Masahiko
Department of Medicine and Biological Science, Gunma University Graduate School of Medicine
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Morimoto Shigeto
Department Of Geriatric Medicine Osaka University Medical School
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SUMINO Hiroyuki
Department of Vascular Medicine, Cardiovascular Hospital of Central Japan (Kitakanto Cardiovascular
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Kurabayashi Masahiko
群馬大学 医学系研究科臓器病態内科学
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Kanda Tsugiyasu
Department of General Medicine, Kanazawa Medical University
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Yu Fei
Department of General Medicine, Kanazawa Medical University
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Saegusa Seiichiro
Department of General Medicine, Kanazawa Medical University
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Nakahashi Takeshi
Department of Geriatric Medicine, Kanazawa Medical University
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Iwai Kunimitsu
Department of Geriatric Medicine, Kanazawa Medical University
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Iwai Kunimitsu
Department Of Geriatric Medicine Kanazawa Medical University
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Saegusa Seiichiro
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Yu Fei
Department Of Epidemiology Ucla School Of Public Health
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Kurabayashi Masahiko
Department Of Cardiology Kanazawa Medical University
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Morimoto Shigeto
Department Of Epidemiological And Clinical Research Information Management Kyoto University Graduate
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Takahashi Takashi
Department Of Applied Chemistry Graduate School Of Science And Engineering Tokyo Institute Of Techno
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Sumino Hiroyuki
Department Of Integrated Japanese Oriental Medicine School Of Medicine Gunma University
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KANDA Tsugiyasu
Department of Cardiology, Prefectural Maebashi Hospital
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Sumino Hiroyuki
Department of Medicine and Biological Science, Gunma University Graduate School of Medicine
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