Bone marrow stem cells contribute to cardioprotection in the late phase of ischemic preconditioning
スポンサーリンク
概要
- 論文の詳細を見る
Ischemic preconditioning (IPC) is a well-known innate phenomenon, in which brief exposure to sublethal ischemia protects organs from subsequent ischemia/reperfusion (I/R) injury. The protective effects after IPC occur in two distinct phases: an early phase and a late phase. However, the exact protective mechanism of IPC is not fully understood, especially in the late phase. Based on increasing evidence that bone marrow stem cells (BMSCs) can repair the injured heart, we investigated whether they also play a role in protecting the heart against I/R injury in the late phase of IPC. We observed an increase in cardioprotective factors in the serum in the early phase, but an increase in BMSCs in the circulating blood in the late phase after remote IPC. Using a heart I/R injury model, we demonstrated that the mobilized BMSCs were recruited into the injured heart and contributed to cardioprotection, especially in the late phase of IPC. Our results indicate that IPC enhances the mobilization and recruitment of BMSCs in the late phase to protect the heart against I/R injury.
- Yamaguchi University School of Medicineの論文
著者
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Matsuzaki Masunori
Yamaguchi University Graduate School of Medicine
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Matsuzaki Masunori
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Matsuzaki Masunori
富山大学 医学部バイオ統計学臨床疫学
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Matsubara Mitsunobu
東北大学 医学部遺伝子医療開発分野
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Mitsui M
Department Of Pediatrics And Child Health Nihon University School Of Medicine
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Matsuoka Mitsuteru
琉球大学医学部 第三内科
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Matsubara Mitsunobu
Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine
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Miyahara Mitsuo
The Second Department Of Internal Medicine Sapporo Medical College
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Miyahara Mitsuo
2nd Dept. Of Intern. Med. Sapporo Med. Coll.
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Matsuzaki Masunori
on behalf of the j-Cypher Registry Investigators
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Matsuoka M
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Matsuzaki Masunori
Department Of Pediatrics And Child Health Nihon University School Of Medicine
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Li Tao-sheng
Department Of Surgery And Clinical Science Yamaguchi University Graduate School Of Medicine
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Mikamo Akihito
Department Of Cardiac Surgery And Clinical Sciences Yamaguchi University Graduate School Of Medicine
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Matsuzaki Masunori
Department Of Surgery And Clinical Science Division Of Cardiac Surgery Yamaguchi University Graduate
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Matsuzaki M.
Yamaguchi University School of Medicine
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Morikage Noriyasu
Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine
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Hamano Kimikazu
Department Of Cardiac Surgery And Clinical Sciences Yamaguchi University Graduate School Of Medicine
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Kobayashi Toshiro
Department Of Cardiac Surgery And Clinical Sciences Yamaguchi University Graduate School Of Medicine
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Matsuzaki Masunori
Division Of Cardiology Department Of Medicine And Clinical Science Graduate School Of Medicine Yamag
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Mochizuki Mamoru
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Miyahara Mitsuo
Dept. Of Intern. Med. (section 2) Sapporo Med. Coll.
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Matsubara Mitsunobu
Division Of Molecular Medicine Tohoku University Graduate School Of Medicine
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Mori Masaki
Division Of Gene Therapy Science Osaka University
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Morikage Noriyasu
Department Of Surgery And Clinical Science Yamaguchi University Graduate School Of Medicine
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Mochizuki Mamoru
Department Of Medicine And Clinical Science Division Of Cardiology Yamaguchi University Graduate Sch
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Matsuzaki Masunori
The Second Department Of Internal Medicine University Of Yamaguchi
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Matsuaki Masunori
Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch
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Matsuzaki Masunori
Japanese Circulation Society Guideline Preparation Group Myocarditis
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Kubo Masayuki
Department Of Surgery And Clinical Science Yamaguchi University Graduate School Of Medicine
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Matsuaki Masunori
Department Of Medical Bioregulation Division Of Cardiovascular Medicine Yamaguchi University School
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Matsumura Masaharu
Department Of Pediatrics And Child Health Nihon University School Of Medicine
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Miyahara Mitsuo
Second Department Of Internal Medicine Sapporo Medical College
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Ohshima Mako
Department Of Surgery And Clinical Science Yamaguchi University Graduate School Of Medicine
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Miyahara Mitsuo
2nd Div. Dept. Of Intern. Med. Sapporo Med. Coll.
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Murakami Masanori
The Second Division Of Internal Medicine Yamaguchi University School Of Medicine
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