Characteristics of Sleep Apnea-hypopnea Syndrome (SAHS) in Elderly Inpatients in a Long-term Care Facility

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概要

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• OBJECTIVES: Sleep apnea-hypopnea syndrome (SAHS) in middle-aged subjects has been well characterized. The majority of SAHS presents as obstructive SAHS (OSAHS). It occurs more often in men, and is associated with cerebro-cardiovascular disease and its risk factors. Although numerous studies have suggested that the prevalence of SAHS is high in the elderly, its precise characteristics are not known. The aim of this study was to investigate the prevalence of SAHS in Japanese elderly inpatients in a hospital for the elderly, and to evaluate its characteristics. METHODS: The study was conducted in Japanese elderly inpatients aged 65 years or older with an admission period of 6 months or longer. The total study subjects consisted of 38 men and 107 women. After screening by pulse oximetry, SAHS patients were diagnosed (apnea-hypopnea index: AHI≥5/h) and classified into subtypes by polysomnography. RESULTS: We identified 46 SAHS patients (12 male and 34 female) out of the 145 subjects. However, there was no significant difference in the characteristics of SAHS, including prevalence (32% each), mean age (79 and 81 years old), and severity [mild/moderate/severe: 5 (13.2%)/6 (15.8%)/1 (2.6%) and 12 (11.2%)/13 (12.1%)/9 (8.4%)], between men and women. On the other hand, polysomnographic examination revealed an apparent predominance of mixed SAHS (MSAHS: 54%) and Cheyne-Stokes breathing syndrome (CSBS: 26%) rather than OSAHS (20%). Well-known factors associated with OSAHS such as hypertension, ischemic heart disease and cerebro-cardiovascular disease and with CSBS such as congestive heart failure in middle-aged subjects showed no significant association with SAHS as a whole or with any subtype of SAHS in the elderly compared to control elderly subjects. CONCLUSION: Compared to SAHS in middle-aged subjects, SAHS in elderly inpatients was characterized by a high prevalence, predominance of MSAHS and CSBS rather than OSAHS, and absence of association with well-known cerebro-cardiovascular factors. The pathogenesis of SAHS in elderly inpatients should be further clarified in the future.

• 金沢医科大学の論文

著者

• MORIMOTO Shigeto

  Kanazawa Medical University

• Matsuzaki Masunori

  Division Of Cardiology Department Of Medicine And Clinical Science Yamaguchi University Graduate Sch

• Morimoto Shigeto

  金沢医科大学 高齢医学科

• Morimoto Shigeto

  Department Of Geriatric Medicine Osaka University Medical School

• OKAISHI Kohya

  Department of Geriatric Medicine, Kanazawa Medical University

• MATSUMOTO Masayuki

  Department of Geriatric Medicine, Kanazawa Medical University

• Matsubara Mitsunobu

  Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine

• Miyahara Mitsuo

  The Second Department Of Internal Medicine Sapporo Medical College

• LIU Wei

  Department of Physiology, China Pharmaceutical University

• Liu Wei

  Department Of Geriatric Medicine Kanazawa Medical University:respiratory Department Of Zhong Nan Hos

• Okaishi Kohya

  Department Of Medicine Sengi-hospital

• Morimoto Shigeto

  Department Of Geriatric Medicine Graduate School Of Medicine Osaka University

• Matsuzaki Masunori

  Department Of Cardiovascular Medicine Yamaguchi University Graduate School Of Medicine

• Morita Satoshi

  Department Of Epidemiological And Clinical Research Information Management Kyoto University Graduate

• Matsumoto Masayuki

  Department Of Geriatric Medicine Kanazawa Medical University

• Miyahara Mitsuo

  Dept. Of Intern. Med. (section 2) Sapporo Med. Coll.

• Mori Masaki

  Division Of Gene Therapy Science Osaka University

• Matsumoto Masayuki

  Department Of Electrical Engineering Faculty Of Engineering Toyo University

• Liu Wei

  Department Of Analytical Chemistry Shenyang Pharmaceutical University

• Morimoto Shigeto

  Department Of Epidemiological And Clinical Research Information Management Kyoto University Graduate

• Morimoto Shigeto

  Department Of Epidemiological And Clinical Research Information Management Kyoto University Graduate

• Matsumoto Masayuki

  Department Of Cardiology Kyushu Kousei-nenkin Hospital

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