The metabolism of estriol-3-glucosiduronate and estriol in the rabbit.

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概要

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• Urinary metabolites of [6, 7-<SUP>3</SUP>H]-estrio1-3-glucosiduronate and of [6, 7-<SUP>3</SUP>H]-estriol in intact female rabbits were analyzed. The separation of urinary metabolites was performed by countercurrent distribution followed by DEAE-Sephadex A-25 column chromatography. Each conjugate was then hydrolyzed with the enzymes and the aglycone thus liberated was identified. In either case, major urinary metabolites were found to be diconjugates, a considerable part of which was glucosiduronate-Nacetylglucosaminide of 17-epiestriol. In addition, estriol-16-glucosiduronate or monoglucosiduronate of 17-epiestriol was identified as a minor urinary metabolite of [6, 7-<SUP>3</SUP>H]-estriol. From these results, it was concluded that the greater part of the estriol-3-glucosiduronate was converted to diconjugates and that estriol-3-glucosiduronate was probably an intermediate metabolite in the conversion pathway from estriol to diconjugates in this species.

• 社団法人 日本内分泌学会の論文

著者

• MIYAZAKI TATSUO

  First Department of Internal Medicine, Faculty of Medicine University of Tokyo

• MIZUKOSHI HIROSHI

  First Department of Internal Medicine, Faculty of Medicine University of Tokyo

• ARAKI YOSHITAKA

  First Department of Internal Medicine, Faculty of Medicine University of Tokyo

• SHIMIZU NAOKATA

  First Department of Internal Medicine, Faculty of Medicine University of Teikyo

関連論文

• The Effects of Aldosterone and Spirolactone on the Renal Sodium and Potassium Excretion During Mannitol Diuresis
• The Metabolism of 17β-Estradio1-3-Glucosiduronate and Estrone-3-Glucosiduronate in the Rabbit
• Constant Infusion of Hypertonic Saline in the Dog II : Compartmental Analysis with Radioactive Sodium
• Survey Studies on Pituitary Diseases in Japan
• The metabolism of estriol-3-glucosiduronate and estriol in the rabbit.

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