The Metabolism of 17β-Estradio1-3-Glucosiduronate and Estrone-3-Glucosiduronate in the Rabbit

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概要

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• [6, 7-<SUP>3</SUP>H]-17β-Estradio1-3-glucosiduronate, [6, 7-<SUP>3</SUP>H]-estrone-3-glucosiduronate or [6, 7-<SUP>3</SUP>H]-estrone was administered intravenously into the rabbit, and analysis and identification of the urinary metabolites were carried out.<BR>In either case, the major urinary metabolite was found to be a diconjugate. The sequential enzymic hydrolysis indicated that this diconjugate was glucosiduronate-Nacetylglucosaminide of 17α-estradiol.<BR>From these results, the conversion of the estrogen glucosiduronate into a diconjugate was thought a rather universal phenomenon in the rabbit.

• 社団法人 日本内分泌学会の論文

著者

• ARAKI YOSHITAKA

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• MIYAZAKI TATSUO

  First Department of Internal Medicine, Faculty of Medicine University of Tokyo

• MIZUKOSHI HIROSHI

  First Department of Internal Medicine, Faculty of Medicine University of Tokyo

関連論文

• The Effects of Aldosterone and Spirolactone on the Renal Sodium and Potassium Excretion During Mannitol Diuresis
• The Metabolism of 17β-Estradio1-3-Glucosiduronate and Estrone-3-Glucosiduronate in the Rabbit
• Constant Infusion of Hypertonic Saline in the Dog II : Compartmental Analysis with Radioactive Sodium
• The metabolism of estriol-3-glucosiduronate and estriol in the rabbit.

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