The Effects of Aldosterone and Spirolactone on the Renal Sodium and Potassium Excretion During Mannitol Diuresis

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概要

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• During mannitol diuresis urinary potassium excretion increased sharply along with sodium excretion under the influence of a large dose of aldosterone, and it remained almost unchanged after 3 days continuous administration of spirolactone. Plots of potassium excretion rates against sodium excretion rates during ordinary mannitol diuresis without any pretreatment distributed between the 2 extremes. The potassium excretion did not vanish even with spirolactone and at low rate of sodium excretion. This implies that urinary K/Na ratio can take any value at various aldosterone levels in the body, and it offers a poor guide for aldosterone activity without referring correspondent sodium excretion rate.Since two regression lines representing the effects of aldosterone and spirolactone can contain plots obtained from some other types of diuresis, it is inferred that they present a common mode of renal tubular activity. Sodium in the tubular fluid is suspected to enter the tubular cell and to exchange with potassium there. Aldosterone may enhance this process. This facet of aldosterone activity seems to derange bodily homeostasis for potassium.

• International Heart Journal刊行会の論文

著者

• Nagasaka Masato

  1st Dept. Of Med. Facul. Of Med. Univ. Of Tokyo

• Takahashi Masao

  1st Dept. of Intern. Med., Faculty of Med., Univ. of Tokyo

• YOSHITOSHI YAWARA

  First Dept. of Intern. Med., Facul. of Med., Univ. of Tokyo

• SEKI Kiyoshi

  First Department of Internal Medicine, Nippon Medical School

• NAGASAKA Masahito

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• KINOUCHI Takashi

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• NAKAMURA Kazumichi

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• ITO Teizo

  First Department of Medicine, Faculty of Medicine, University of Tokyo

• TAKAHASHI Masao

  First Department of Medicine, Faculty of Medicine, University of Tokyo

• KUROSAWA Takeshi

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• ARAKI YOSHITAKA

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• Nagasaka Masahito

  1st Dept. Of Med. Facul. Of Med. Univ. Of Tokyo

• Nagase Mitsumasa

  Univ. Of Tokyo 1st Dept. Of Intern. Med.

• ITO Teizo

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• ARAKI YOSHITAKA

  First Department of Internal Medicine, Faculty of Medicine University of Tokyo

• YOSHITOSHI Yawara

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• SEKI Kiyoshi

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• TAKAHASHI Masao

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

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