クリアランス法による腎機能および抗利尿物質に關する研究

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概要

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• I performed the study on kidney function for the purpose of clearing the genesis of edema. In the patients with edematous diseases, I measured GFR, RPF, TmPAH, TmG, electrolytes (Na, K, Cl) clearance and antidiuretic substance (ADS) in serum and urine. First, I compared the kidney function of edematous states with that of non-edematous states. Generally, GFR was less than about 80 cc/min. in the edematous cases, but edema did not always appear below this value. RPF, TmG, TmPAH also decreased in edematous states. From these facts, the genesis of edema is not cleared by only the decrease in the kidney function. Then, I supposed that humoral factors take some parts. I noticed that ADS increased in serum and urine of edematous states and that this increase was not paralleled to the grade of edema in some cases. In edematous states, Na, Cl clearances decreased and K clearance did not show a constant change. Next, I studied the diuretic effects in edematous diseases when many diuretics and organ preparates were administerd to edematous patients. Digitalis glycosides, mercurial diuretics, diamox, mictine and theophylline preparates, and cortisone, insulin and pitressin were used for this study. Each preparate had various effect upon the kidney function. Then, I observed the action of heat and rectangular low frequency current upon the human kidney. In 19 cases, antityphoid vaccine and TTG were inoculated and in 21 cases hot bathing, cold pressor test, spinal electrification of low frequency of rectangular pulse were examined. In many cases, the kidney function temporarily decreased and ADS of serum increased. This condition occured shortly after the administration of drug and electrification and appeared a kind of shock. I used TTG for the fever therapy, and in the rectangular low frequency current therapy I regulated very slowly the grade of the electrification at the beginning and the end. Then I noticed that the kidney function was scarecely varied.

• 社団法人 日本内科学会の論文

著者

• 高橋 政夫

  茅ヶ崎徳洲会病院胸部心臓血管外科

• Takahashi Masao

  1st Dept. of Intern. Med., Faculty of Med., Univ. of Tokyo

• TAKAHASHI Masao

  First Department of Medicine, Faculty of Medicine, University of Tokyo

• 高橋 政夫

  東京大學医學部田坂内科教室

• TAKAHASHI Masao

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

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