The Role of Aldosterone in the Pathogenesis of Congestive Heart Failure

スポンサーリンク

概要

• 論文の詳細を見る

• The effect of aldosterone on electrolytes and water diuresis was examined on 3 groups of human and dog, i.e. normal, mild heart disease and congestive failure.In control group, the administration of d-aldosterone prior to mannitol or saline infusion led to a large amount of potassium diuresis but did not decrease sodium excretion in urine. This phenomenon is regarded as the initial effect of aldosterone for electrolytes and water diuresis.In patients and dogs with heart disease without edema, however, aldosterone showed differential effects between mannitol and saline infusion. By mannitol, potassium excretion was unchanged despite reduced sodium excretion, but by saline the former was increased and the latter was unchanged.In patients and dogs with congestive heart failure, whether on mannitol or on saline, the pre-treatment of aldosterone minimized the sodium excretion in urine, but the potassium excretion was almost as same as that in normal cases and in mild heart disease.These observations lead to the following conclusions.(1) The increased aldosterone secretion itself is not the only necessary cause of edema.(2) The sodium in renal tubules is reabsorbed by 2 ways; one is through Na-K exchange and the other is effected by the sodium reabsorption independent of Na-K exchange, and aldosterone can act on both processes differently according to the condition of patient or animal.(3) The second way will act in initial effect and escape phenomenon in normal human and dog, but it will show the strong sodium retaining effect in human and dog with congestive heart failure.(4) Aldosterone may probably aggravate the edema in congestive heart failure, but it might not be the primary cause of edema and its primary cause is rather the altered tubular responsiveness to aldosterone.

• International Heart Journal刊行会の論文

著者

• Takahashi Masao

  1st Dept. of Intern. Med., Faculty of Med., Univ. of Tokyo

• Ito Teizo

  1st Div. Dept. Of Intern. Med. Facul. Of Med. University Of Tokyo

• YOSHITOSHI YAWARA

  First Dept. of Intern. Med., Facul. of Med., Univ. of Tokyo

• SEKI Kiyoshi

  First Department of Internal Medicine, Nippon Medical School

• HANAOKA WAICHIRO

  First Dept. of Intern. Med., Facutly of Med., Univ.

• NAGASAKA Masahito

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• KINOUCHI Takashi

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• NAKAMURA Kazumichi

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• ITO Teizo

  First Department of Medicine, Faculty of Medicine, University of Tokyo

• TAKAHASHI Masao

  First Department of Medicine, Faculty of Medicine, University of Tokyo

• KUROSAWA Takeshi

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• OHSHIMA Motochika

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• MAEDA Teiryo

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• ITO Teizo

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• YOSHITOSHI Yawara

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• HANAOKA Waichiro

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• SEKI Kiyoshi

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• TAKAHASHI Masao

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

関連論文

• STUDIES ON THE MECHANISMS OF EDEMA FORMATION AND DIURESIS (IX) THE RELATIVE IMPORTANCE OF PLASMA SODIUM CONCENTRATION AND GFR IN THE RENAL SODIUM EXCRETION : Proceedings of the 34th Annual Meeting of the Japanese Circulation Society (Part I)
• Studies on Edema (XXII) : The Effect of d-Aldosterone on the Renal Tuble on Patients with Edema and Dogs
• 134) On the Relation between Action Potential Duration and Frequency of Stimulation in the Cardiac Muscle Cell : The Influence of Extracellular Electrolyte Concentration on the Digitalis Effect
• 118) Relationship between Hypopotassemic ECG and Tissue Potassium
• 137. Effects of Postural Change and Amyl Nitrite on Pulmonary Blood Volume
• A CLINICAL STUDY ON DIGITALIS INTOXICATION
• Multiclinical Open Studies on the Effect of β-Methyldigoxin on Congestive Heart Failure with Atrial Fibrillation
• 65. Ventricular Fibrillation Threshold (VFRT) in Experimental Coronary Occlusion : A Comparative Study on the Effect of G-I-K Solution and Some New Antiarrhythmic Drugs
• Effect of "Short-term" Hypertension on the Uptake of C14-Cholesterol by the Aortic Wall of the Rat
• Sodium Excretion in Volume-Expanded Dogs : I. Comparison of the Effects of Physiological Saline and 5% Glucose Solution
• QT Duration and Plasma Electrolytes (Ca, Na, and K) in Uremic Patients
• Constant Infusion of Hypertonic Saline in the Dog : V. The Relative Importance of Plasma Na Concentration and GFR as the Determinants of Renal Na Excretion
• Constant Infusion of Hypertonic Saline in the Dog : III. Effects of Physiologic Saline Preloading and of Aldosterone Thereon
• Constant Infusion of Hypertonic Saline in the Dog : I. Kinetic Analysis
• The Effects of Aldosterone and Spirolactone on the Renal Sodium and Potassium Excretion During Mannitol Diuresis
• Depletion of the Renal Medullary Osmotic Gradient Following Hemorrhagic Hypotension in Hydropenic Rabbits
• Quantitative Relationship between Serum Ca and Inorganic Phosphate Concentrations in Uremic Patients
• Constant Infusion of Hypertonic Saline in the Dog : IV. Effect of Acute Aortic Constriction on Sodium Excretion
• The Role of Aldosterone in the Pathogenesis of Congestive Heart Failure
• Renal Hemodynaniics and Medullary Osmolal Gradient in Ischemic Acute Renal Failure in Rabbits
• Alterations in the Intrarenal Hemodynamics Following Changes in Ureteral Pressure in the Rabbit Kidney
• Alterations in the Renal Hemodynamics Induced by Increased Renal Vein Pressure in the Rabbit Kidney
• Experimental Studies on the Beriberi Heart : III. Correct Treatment Doses of Thiamine for the Beriberi Heart Disease and Effects of Vitacampher and Norepinephrine
• Experimental Studies on the Beriberi Heart : II. Effect of Starvation and Role of Vagus Nerve
• Experimental Studies on the Beriberi Heart : I. Cardiac Lesions in Thiamine Deficient Rats
• クリアランス法による腎機能および抗利尿物質に關する研究
• Constant Infusion of Hypertonic Saline in the Dog II : Compartmental Analysis with Radioactive Sodium
• Response of Plasma Aldosterone to Postural Change, Diuretica, Angiotensin II, Sodium Restriction or Loading and Prostaglandin
• Effects of Saline Infusion on Prostaglandin-like Materials in Renal Venous Blood and Medulla of Canine Kidney
• Free Water Excretion and Washout of Renal Medullary Urea by Prostaglandin E1
• Compartmental Analysis of Sodium Dynamics in Non-Edematous, Edematous and Uremic Patients
• Clinical Feature of Myocardial Infarction in Japan

もっと見る 閉じる

スポンサーリンク