Multiclinical Open Studies on the Effect of β-Methyldigoxin on Congestive Heart Failure with Atrial Fibrillation

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概要

• 論文の詳細を見る

• Clinical open trials of β-methyldigoxin were carried out in 15 institutions in order to examine the effect, usefulness and ease of its oral administration.In the case of oral digitalization with 0.2mg, 3 times daily, an effect was obtained in all of 13 cases of congestive heart failure accompanied by atrial fibrillation or flutter. The average time and dose required for digitalization were about 50 hours and 1.27mg respectively. In 9 of the 13 cases, the effect was achieved within 48 hours.The average maintenance does of β-methyldigoxin in 102 cases of congestive heart failure with atrial fibrillation was 0.177mg per day. About 75% of the cases were maintained with 0.15 to 0.2mg. This range of dose of β-methyldigoxin was much smaller than that of digoxin in our series. This can be ascribed to a higher absorption rate of β-methyldigoxin from the digestive tract.Studies on the cases in which patients previously treated with other glycosides were switched over to β-methyldigoxin revealed that 1mg of β-methyldigoxin is equivalent to 1.8mg of digoxin or to 0.59mg of digitoxin.The usefulness and ease of β-methyldigoxin in maintenance was evaluated as being somewhat superior to other cardiac glycosides, according to the global judgement of the physicians. The observed side effects were similar to those of other glycosides in frequency and character.

• International Heart Journal刊行会の論文

著者

• ITO Yoshio

  First Department of Internal Medicine, Nippon Medical School

• SEKI Kiyoshi

  First Department of Internal Medicine, Nippon Medical School

• KIMURA Eiichi

  First Department of Internal Medicine, Nippon Medical School

• SEKI Kiyoshi

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

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