Constant Infusion of Hypertonic Saline in the Dog : V. The Relative Importance of Plasma Na Concentration and GFR as the Determinants of Renal Na Excretion

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概要

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• Renal Na excretion correlated well with the product of elevation in plasma Na concentration from original value and GFR, as was suspected from the kinetic model. This was found to be true in the control hypertonic saline diuresis and in the physiologic saline preloading experiment. However, in experiment with aortic constriction correlation was unsatisfactory.Relative importance of elevation in plasma Na concentration and GFR was estimated by multiple regression analysis. Their importance was similar and original regression equation was verified in the control and the saline preloading experiment. However, in the aortic constriction experiment, while weight for elevation of plasma Na concentration remained unchanged, that for GFR was almost eliminated. This finding may be to explain the reported irrelevance of GFR to renal Na excretion during massive saline diuresis. It is postulated that manipulation of large artery system is the cause of this apparent irrelevance. Further, when GFR was reduced drastically by aortic constriction, renal Na excretion was again larger than was predicted by the regression equation with small coefficient for GFR.

• International Heart Journal刊行会の論文

著者

• Nagasaka Masato

  1st Dept. Of Med. Facul. Of Med. Univ. Of Tokyo

• Takahashi Masao

  1st Dept. of Intern. Med., Faculty of Med., Univ. of Tokyo

• YOSHITOSHI YAWARA

  First Dept. of Intern. Med., Facul. of Med., Univ. of Tokyo

• NAGASAKA Masahito

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• KINOUCHI Takashi

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• NAKAMURA Kazumichi

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• ITO Teizo

  First Department of Medicine, Faculty of Medicine, University of Tokyo

• TAKAHASHI Masao

  First Department of Medicine, Faculty of Medicine, University of Tokyo

• Nagasaka Masahito

  1st Dept. Of Med. Facul. Of Med. Univ. Of Tokyo

• Nagase Mitsumasa

  Univ. Of Tokyo 1st Dept. Of Intern. Med.

• ITO Teizo

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• YOSHITOSHI Yawara

  First Department of Medicine, Faculty of Medicine, University of Tokyo

• YOSHITOSHI Yawara

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• TAKAHASHI Masao

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

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