Constant Infusion of Hypertonic Saline in the Dog : I. Kinetic Analysis

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概要

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• 10% saline solution was infused in the dogs by constant infusion and single injection, and the changes in plasma Na concentration and urinary Na excretion rate were followed. The responses of animal to the two types of saline loading were analyzed in terms of a single capacitive system and a two compartment model. The two compartment model was con-structed by one extracellular and another intracellular compartments connected by leak at the cellular membrane and Na pump at the same site and by modulation of renal reabsorption of Na by the intracellular Na concentration. In the dog kidney, the experimental results were accounted for better by the threshold theory of the Na reabsorption than by the constant fractional reabsorption theory. Advantages and incompletenesses in the present model were discussed.

• International Heart Journal刊行会の論文

著者

• Nagasaka Masato

  1st Dept. Of Med. Facul. Of Med. Univ. Of Tokyo

• Takahashi Masao

  1st Dept. of Intern. Med., Faculty of Med., Univ. of Tokyo

• YOSHITOSHI YAWARA

  First Dept. of Intern. Med., Facul. of Med., Univ. of Tokyo

• NAGASAKA Masahito

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• KINOUCHI Takashi

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• NAKAMURA Kazumichi

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• ITO Teizo

  First Department of Medicine, Faculty of Medicine, University of Tokyo

• TAKAHASHI Masao

  First Department of Medicine, Faculty of Medicine, University of Tokyo

• Nagasaka Masahito

  1st Dept. Of Med. Facul. Of Med. Univ. Of Tokyo

• Nagase Mitsumasa

  Univ. Of Tokyo 1st Dept. Of Intern. Med.

• ITO Teizo

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• YOSHITOSHI Yawara

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

• TAKAHASHI Masao

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

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