Suppressive Effect of Cyproheptadine on L-DOPA-induced Growth Hormone Release in Man
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概要
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In order to elucidate the relationship between dopaminergic and serotoninergic mechanisms in regulating secretion of human growth hormone (hGH), the effect of cyproheptadine, an antiserotoninergic agent, on 1-DOPA-induced hGH secretion was studied in normal subjects. Oral administration of 500 mg of 1-DOPA caused a rise in plasma hGH in 6 of 7 subjects studied. This rise in plasma hGH was significantly blunted by the intravenous infusion of 5 mg of cyproheptadine. These results suggest the close relationship between dopamine and serotonin in the control of hGH secretion.
- 社団法人 日本内分泌学会の論文
著者
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Imura Hiroo
Third Division, Department of Medicine, Kobe University School of Medicine
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Nakai Yoshikatsu
Second Division, Department of Medicine, Kyoto University School of Medicine
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Imura Hiroo
Third Division Department Of Medicine Kobe University School Of Medicine
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Nakai Yoshikatsu
Second Division Department Of Medicine Kyoto University School Of Medicine
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