IMMUNOHISTOCHEMICAL DISTRIBUTION OF NEUROPEPTIDES IN THE RAT CENTRAL NERVOUS SYSTEM
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概要
- 論文の詳細を見る
The authors studied the distribution of met-enkephalin, α-endorphin, β-endorphin and LHRH within the central nervous system of rats by the indirect immunofluorescent technique, and observed α-endorphin-like immunoreactivity in the median eminence adjoining the portal vein as nerve terminals of dot-like immunofluorescence. This finding deserves special attention since α-endorphin has been considered physiologically inactive. Nerve terminals of α-endorphin-, β-endorphin- and met-enkephalin-like immunoreactivities were immunohistochemically confirmed in the medial hypothalamus. These results positively suggested that this area was playing comprehensive roles in physiological functions of the hypothalamo-pituitary system. To visualize neuropeptide-containing nerve cell bodies, we applied the immunofluorescent technique on various neuropeptides to intraventricularly colchicine injected rats. Some LHRH and met-enkephalin containing nerve cell bodies were observed without colchicine, though. All of substance P-, LHRH- and met-nekephalin-positive nerve cell bodies were visualized in the ventromedial hypothalamic nucleus, substance P- and β-endorphin positive nerve cell bodies in the arcuate nucleus, substance P-positive ones in the posterior hypothalamic nucleus and met-enkephalin-positive ones in the dorsomedial hypothalamic nucleus. Besides, substance P-containing and met-enkephalin-containing nerve cell bodies were coexisting in the mesencephalic central gray matter. α-Endorphin-containing nerve cell bodies were also noticed in the caudate nucleus. In addition, calcitonin-like immunoreactive cell bodies were observed in the anterior lobe of the pituitary body.
- 日本組織細胞化学会の論文
著者
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KITO Shozo
Third Department of Internal Medicine, Hiroshima University, School of Medicine
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YANAIHARA NOBORU
Shizuoka College of Pharmacy
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Kito Shozo
Third Department Of Internal Medicine Hiroshima University School Of Medicine
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Kito Shozo
Third Department Of Internal Medicine Hiroshima University
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Ogawa Norio
Institute For Neurobiology Okayama University Medical School
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Saito Shiro
Department Of Urology National Hospital Organization Tokyo Medical Center
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KISHIDA Takenobu
Third Department of Internal Medicine, Hiroshima University School of Medicine
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ITOGA Eiko
Third Department of Internal Medicine, Hiroshima University School of Medicine
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OGAWA NORIO
Third Department of Internal Medicine, Okayama University Medical School
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Itoga Eiko
Third Department Of Internal Medicine Hiroshima University School Of Medicine
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Kishida Takenobu
Third Department Of Internal Medicine Hiroshima University School Of Medicine
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Saito Shiro
Department Of Laboratory Medicine School Of Medicine Tokushima University
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Saito Shiro
Department Of Laboratory Medicine Tokushima University School Of Medicine
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SAITO SHIRO
Department of Clinical Laboratory, Tokushima University Hospital, Faculty of Medicine Tokushima University
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