BINDING EXPERIMENTS OF MUSCARINIC ACETYLCHOLINE AND DOPAMINE RECEPTORS IN HUMAN BRAINS WITH EMPHASIS ON A CASE OF STRIATONIGRAL DEGENERATION
スポンサーリンク
概要
- 論文の詳細を見る
In the regional distribution of /-<SUP>3</SUP>H-quinuclidinyl benzilate (<SUP>3</SUP>H-QNB) binding in human brains of neurologically unaffected cases, it was highest in the caudate nucleus which was followed by the putamen, amygdala, cerebral corteces and olfactory bulb and lowest in the substantia nigra. As to the regional distribution of <SUP>3</SUP>H-spiroperidol binding in human control brains, it was highest in the caudate nucleus and was followed by the cerebral corteces, amygdala and lowest in the cerebellar cortex. In a case of striatonigral degeneration (SND), <SUP>3</SUP>H-QNB binding in the putamen and thalamus was lowered and <SUP>3</SUP>H-spiroperidol binding was decreased in the putamen, frontal and parietal corteces, Ammons horn, amygdala and substantia nigra as compared to human brains of control cases. These results were noteworthy since no pathological changes were observed in the thalamus, cerebral corteces, amygdala and Ammons horn in this case. The <SUP>3</SUP>H-spiroperidol binding was increased by injection of 6-hydroxy-dopamine (6-OHDA) into the substantia nigra of rat brains by 17% as compared to the contralateral intact side. Conversely, <SUP>3</SUP>H-spiroperidol binding was decreased by injection of kainic acid (KA) into the striatum of rat brains by 43% as compared to the contralateral intact side. This meant that dopamine receptors labelled by <SUP>3</SUP>H-spiroperidol were at least partially localized at the postsynaptic site of the nigrostriatal dopamine neuron.
- 社団法人 日本薬理学会の論文
著者
-
Kito Shozo
Third Department Of Internal Medicine Hiroshima University
-
KISHIDA Takenobu
Third Department of Internal Medicine, Hiroshima University School of Medicine
-
Itoga Eiko
Third Department Of Internal Medicine Hiroshima University School Of Medicine
-
Kishida Takenobu
Third Department Of Internal Medicine Hiroshima University School Of Medicine
-
SHIMOYAMA Masanori
Third Department of Internal Medicine, Hiroshima University School of Medicine
-
NANBA Koji
Laboratory of Pathology, Kure MUtual Aid Hospital
関連論文
- Distribution and Ultrastructural findings of Calcitonin Gene-Related Peptide(CGRP) immnoreactive fibers in the Caudate Putamen of the Rat
- The Coexistence of Somatostatin with Substance P and Corticotropin Releasing Factor with Neurotensin-like Immunoreactivity in Single neurons of the Central Nucleus of the Amygdala in the Rat
- Synaptic input from dopaminergic fibers to neuropeptide Y neurons in the rat neostriatum.
- Fine structures of CCK-8 and enkephalin immunoreactive profiles in the hypothalamic ventromedial nucleus of rat.
- Behayior studies after intracaudate kainate injection and evidence of the straiato-pallidal met-enkephalinergic pathway
- IMMUNOHISTOCHEMICAL DISTRIBUTION OF NEUROPEPTIDES IN THE RAT CENTRAL NERVOUS SYSTEM
- ULTRASTRUCTURAL LOCALIZATION OF NEUROPEPTIDES IN THE RAT PRIMARY SENSORY NEURONES
- The Biologically Active Polypeptides in the Rat Central Nervous System
- Ultrastructural Localization of Substance P-, Somatostain-, Met-enkephalin- and β-endorphin-like Immunoreactivities in Rat Sensory Ganglia and in Cultured Dorsal Root Ganglion Cells
- IMMUNOHISTOCHEMICAL STUDIES ON THE DISTRIBUTION OF BIOLOGICALLY ACTIVE OLIGOPEPTIDES IN THE RAT CENTRAL NERVOUS SYSTEM
- Distribution and Fine Structures of Neuropeptide Y Immunoreactive Neurons in the Rat Claustrum
- Topographical Study of Rat Basal Forebrain-cortex Connection.
- Distributions of Amino Acidic Neurotransmitter Receptors in Normal Rat and Human Brains
- Ontogenetic Studies of ^3H-substance P Binding Sites in the Rat Brain
- Autoradiographic distribution of ^3H-lisuride binding sites in rat brain
- Calcium antagonist binding sites in the rat central nervous system
- Degeneration of AChE posotive neurons in rat hippocampus
- Mapping of Somatostatin Receptor Localization in Rat Brain
- QUANTITATIVE IN VITRO AUTORADIOGRAPHY OF NEUROTRANSMITTER RECEPTORS : APPLICATIONS TO DISEASED HUMAN BRAINS
- Relationship Between 3H-flunitrazepam Binding Sites and Distribution of GAD-like Immunoreactivity within the Rat Brain
- MORPHOLOGICAL STUDY ON γ-AMINOBUTYRIC ACID AND MET-ENKEPHALIN RECEPTORS IN THE RAT BRAIN (HISTOCHEMICAL APPROACHES TO THE RECEPTORS)
- Immnunohistochemical studies of pancreatic glucagon in the rat hypothalamus
- Neuropeptide and catecholamine relationship in the brain from morphological viewpoints.
- BINDING EXPERIMENTS OF MUSCARINIC ACETYLCHOLINE AND DOPAMINE RECEPTORS IN HUMAN BRAINS WITH EMPHASIS ON A CASE OF STRIATONIGRAL DEGENERATION
- Distribution and Characterization of ^I-CGRP Binding Sites in the Human and Rat brains
- Distribution and Connections of Neuropeptide Y Immunoreactive Neurons in the Rat Claustrum and the Entorhinal cortex
- Autoradiographic Studies on Benzodiazepine Receptor Subtypes in the Rat Brain
- Effects of neurotransmitters or drugs on the in vivo release of dopamine and its metabolites.
- Quantitative autoradiographic localization of the M1 and M2 subtypes of muscarinic acetylcholine receptors in the monkey brain.