Concomitant Production of β-Endorphin in Ectopic ACTH/β-LPH-Producing Tumors
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概要
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It is generally accepted that ectopic ACTH-producing tumors produce not only ACTH but β-MSH or β-LPH as well. Using a sensitive radioimmunoassay for βhendorphin, we have demonstrated the presence of β-endorphin immunoreactivity with size heterogeneity according to Sephadex gel chromatography and sodium dodecyl sulfate polyacrylamide gel electrophoresis in 6ectopic ACTH/β-LPH-producing tumors, providing further evidence for the role of a common precursor to ACTH and β-LPH/β-endorphin in the peptide biosynthesis in these tumors, in a manner similar to the biosynthetic events in the pituitary gland of several species.
- 社団法人 日本内分泌学会の論文
著者
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Hirata Yukio
Third Division Department Of Medicine Kobe University School Of Medicine
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Matsukura Shigeru
Third Department Of Internal Medicine Miyazaki Medical College
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Fujita Takuo
Third Department Of Internal Medicine Kobe University School Of Medicine
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YOSHIMI HIROKI
Third Division, Department of Medicine, Kobe University School of Medicine
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SUEOKA SATORU
Third Division, Department of Medicine, Kobe University School of Medicine
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YOKOTA MAKOTO
Third Division, Department of Medicine, Kobe University School of Medicine
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