Expression of mPOU Protein in the Human Pituitary Adenomas
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概要
- 論文の詳細を見る
[Objective] mPOU is a POU protein classified as class VI. It is present in the pituitary gland as well as the brain, heart muscle, skeletal muscle, lung, and lymphocytes. In our previous investigation, mPOU bound to the Pit-1-binding DNA elements of the rat PRL gene, and promoted transcription of the GH and PRL genes. In this study, we immunohistologically investigated the expression of mPOU in pituitary adenomas. [Methods] 17 patients with pituitary adenoma underwent tumor excision by transsphenoidal approach at our hospital (PRL: 5, GH: 4, FSH: 1, non-functioning: 7). The expression in the tissue sections was investigated using immunostaining (ABC method). [Results] In all GH-producing and PRL-producing adenomas, mPOU protein was specifically expressed, particularly in the nuclei. [Discussion] Pit-1 has been considered to be a factor determining the expression of GH and PRL genes, but mPOU may also be involved in the expression.
- 神戸大学の論文
著者
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Chihara Kazuo
Kobe University Graduate School of Medicine
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Chihara K
Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr
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Chihara Kazuo
Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr
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Kohmura Eiji
Kobe University Graduate School Of Medicine
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Kondoh Takeshi
Kobe University Graduate School of Medicine
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OKIMURA YASUHIKO
Department of Basic Allied Medicine, Kobe University School of Medicine
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Sakagami Yoshio
Kobe University Graduate School of Medicine
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Okimura Yasuhiko
Kobe University Graduate School of Medicine
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Iguchi Genzo
Kobe University Graduate School of Medicine
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Fumoto Mariko
Kobe University Graduate School of Medicine
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Kuno Takayoshi
Kobe University Graduate School of Medicine
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Iguchi Genzo
Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr
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Fumoto Mariko
Division Of Pathology Department Of Pathologyµbiology Kobe University Graduate School Of Me
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Kondoh Takeshi
Division Of Pathology Department Of Pathologyµbiology Kobe University Graduate School Of Me
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Okimura Yasuhiko
Department Of Basic Allied Medicine Kobe University School Of Medicine
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Kuno Takayoshi
Kobe Univ. Graduate School Of Medicine Kobe Jpn
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Kuno Takayoshi
Kobe University Graduate School Of Medicine/kobe University Graduate School Of Medicine
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Chihara Kazuo/Kohmura
Kobe University Graduate School of Medicine
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Kondo Takeshi
Kobe University Graduate School of Medicine
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Chihara Mazuo
Kobe University Graduate School of Medicine
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