Sequence Specificity of the 8-Hydroxyguanine Repair Activity in Rat Organs
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概要
- 論文の詳細を見る
The base excision repair system for 8-hydroxyguanine (8-OH-Gua) is believed to play a role in the prevention of mutations, such as GC-to-TA transversion, which leads to cancer development. However, the exact repair mechanism is still unclear. In this study, we examine whether the repair activity level for 8-hydroxyguanine, one of the major forms of oxidative DNA damage, depends on the sequence of the substrate DNA. We prepared six different oligonucleotides containing 8-hydroxyguanine as substrates and reacted them with crude extracts from the livers and kidneys of 8-week-old Sprague-Dawley rats. As a result, up to a 10-fold difference in the repair activity levels was observed, depending on the substrates used. Based on this observation, we suggest that the repair systems may act with sequence specificity on the damaged DNA.
- 日本放射線影響学会の論文
著者
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Higashi Ken
Department Of Environmental Oncology University Of Occupational And Environmental Health
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HIRANO Takeshi
Department of Clinical Pharmaceutics & Therapeutics, Graduate School of Pharmaceutical Sciences, Hok
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Kasai Hiroshi
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occ
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Kasai Hiroshi
Department Of Environmental Oncology Institute Of Industrial Ecological Sciences University Of Occup
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KAJI HIDESUKE
College of Nursing Art and Culture 13-71
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HIRANO HIDEYASU
Departments of Biochemistry, University of Occupational and Environmental Health
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YAMAGUCHI RAIZO
Departments of Environmental Oncology, University of Occupational and Environmental Health
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ASAMI SHINYA
Departments of Environmental Oncology, University of Occupational and Environmental Health
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TSURUDOME YOSUKE
Departments of Environmental Oncology, University of Occupational and Environmental Health
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Asami S
Univ. Occupational And Environmental Health Kitakyushu
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Asami Shinya
Department Of Ennvironmental Oncology Institute Of Industrial Ecological Sciences
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Hirano Hideyasu
Department Of Biochemistry School Of Medicine University Of Occupational And Environmental Health
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Hirano Hideyasu
Departments Of Biochemistry University Of Occupational And Environmental Health
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Yamaguchi Raizo
Departments Of Environmental Oncology University Of Occupational And Environmental Health
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Kasai H
Department Of Environmental Oncology University Of Occupational And Environmental Health
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Tsurudome Yosuke
Departments Of Environmental Oncology University Of Occupational And Environmental Health
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Kasai H
Department Of Environmental Oncology Institute Of Industrial Ecological Sciences University Of Occup
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Kasai Hiroshi
Department Of Ennvironmental Oncology Institute Of Industrial Ecological Sciences
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Hirano T
Photon Medical Research Center Hamamatsu University School Of Medicine
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Hirano Takeshi
Department Of Environmental Oncology University Of Occupational And Environmental Health:(present Ad
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Kasai H
Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr
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Hirano Takeshi
Department Of Anatomy University Of Occupational And Environmental Health School Of Medicine
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