Fragmentation of the DNA Repair Enzyme, OGG1, in Mouse Nonparenchymal Liver Cells by Arsenic Compounds
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概要
- 論文の詳細を見る
Our previous work demonstrated that arsenic compounds increased 8-hydroxyguanine (8-OH-Gua) in the DNA of cultured human cells (A549) and reduced the endonuclease nicking activity for 8-OH-Gua, suggesting that arsenic compound-induced carcinogenesis was the consequence of the inhibition of DNA repair. However, the exact mechanism by which the repair systems were disturbed was unknown. To elucidate the mechanism, we analyzed mouse 8-oxoguanine DNA glycosylase 1 (mOGG1) expression in mouse nonparenchymal liver cells, NCTC, treated with arsenic compounds (arsenic trioxide, sodium arsenite, and sodium hydrogen arsenate). We detected a cleaved form of mOGG1 (35 kDa) in addition to normal mOGG1 (type 1a, 38 kDa) in NCTC treated with arsenic compounds. These results are similar to our previous results which showed that fragmentation of mOGG1 by etoposide was related to caspase-dependent apoptosis, and was accompanied by increased 8-OH-Gua accumulation. Taken together, our results suggested that arsenic compounds might increase 8-OH-Gua accumulation by inhibiting 8-OH-Gua repair, due to mOGG1 cleavage.
- 日本環境変異原学会の論文
- 2006-05-31
著者
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Higashi Ken
Department Of Environmental Oncology University Of Occupational And Environmental Health
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HIRANO Takeshi
Department of Clinical Pharmaceutics & Therapeutics, Graduate School of Pharmaceutical Sciences, Hok
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Kasai Hiroshi
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occ
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Kawai Kazuaki
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occ
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Kawai Kazushige
Department Of Surgical Oncology Faculty Of Medicine The University Of Tokyo
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Kasai Hiroshi
Department Of Environmental Oncology Institute Of Industrial Ecological Sciences University Of Occup
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KAJI HIDESUKE
College of Nursing Art and Culture 13-71
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Ootsuyama Yuko
Department of Environmental Oncology, University of Occupational and Environmental Health
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Ootsuyama Yuko
Department Of Environmental Oncology University Of Occupational And Environmental Health
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Kasai H
Department Of Environmental Oncology University Of Occupational And Environmental Health
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Kasai H
Department Of Environmental Oncology Institute Of Industrial Ecological Sciences University Of Occup
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Kasai Hiroshi
Department Of Ennvironmental Oncology Institute Of Industrial Ecological Sciences
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Hirano T
Photon Medical Research Center Hamamatsu University School Of Medicine
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Kawai Kazuaki
Department Of Environmental Oncology Institute Of Industrial Ecological Sciences University Of Occup
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Kawanami Kiyoshi
Department Of Environmental Oncology Institute Of Industrial Ecological Sciences University Of Occup
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Hirano Takeshi
Department Of Environmental Oncology University Of Occupational And Environmental Health:(present Ad
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Kasai H
Division Of Diabetes Metabolism And Endocrinology Department Of Internal Medicine Kobe University Gr
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Hirano Takeshi
Department Of Anatomy University Of Occupational And Environmental Health School Of Medicine
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Ootsuyama Yuko
Department Of Environmental Oncology Institute Of Industrial Ecological Sciences University Of Occupational And Environmental Health
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Kawai Kazuaki
Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
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