Blunt Cell Growth Potential in Carcinogen Resistant Inbred DRH Rats
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概要
- 論文の詳細を見る
A carcinogen-resistant inbred strain DRH/Sea has been developed from the Crj:Donryu strain. The rats had a very low incidence of liver tumors when they were fed diets containing a hepatocarcinogen such as 3-methyl-4-dimethylamino-azobenzene (3-Me-DAB). Despite using 3-Me-DAB during the stage of selection, the DRH/Sea rats developed normally, reproduced and did not have any spontaneous tumor in the lung, liver or uterus at over 1 year of age. Although their growth curves were similar to the Crj:Donryu rats, the progression of polyploidization in the liver was significantly delayed when compared with Crj:Donryu rats. Mitogenic changes that occurred in the liver caused by either 3-Me-DAB or lead nitrate were less significant in the DRH rats than in Crj:Donryu rats. Furthermore, the growth rate of cultured fibroblasts derived from the DRH rats was slower than that of Crj:Donryu rats. These results, together with our previous results, suggest that slow growth potential is present under certain conditions in DRH rats. These findings may explain partly the meaning of the different susceptibility to hepatocarcinogens.
- 社団法人 日本実験動物学会の論文
著者
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Higashi Ken
Department Of Environmental Oncology University Of Occupational And Environmental Health
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Yan Ying
Department Of Biochemistry School Of Medicine University Of Occupational And Environmental Health
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Yan Ying
Department Of Applied Physics And Chemistry The University Of Electro-communications
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Hamada Yuji
Seac Yoshitomi Ltd
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Hamada Yuji
Seac Yoshitomi Ltd.
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FUKAMACHI Yukiyo
Departments of Biochemistry
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GOTOH Sadao
Department of Biochemistry University of Occupational and Environmental Health
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Higashi Ken
Department Of Biochemistry School Of Medicine University Of Occupational And Environmental Health
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Fukamachi Yukiyo
Department Of 2nd Surgery School Of Medicine Tokyo Women's Medical University
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Gotoh Sadao
Department Of Biochemistry School Of Medicine University Of Occupational And Environmental Health
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Hirano Takeshi
Department Of Environmental Oncology University Of Occupational And Environmental Health:(present Ad
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HIGASHI Taneaki
College of Nutrition, Koshien University
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YAMASHIRO Kenzo
Department of 3rd Internal Medicine
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OHTSUKI Makoto
Department of 3rd Internal Medicine
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Yamamura K
Department Of 3rd Internal Medicine
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Higashi K
Department Of Biochemistry School Of Medicine University Of Occupational And Environmental Health
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Higashi Taneaki
College Of Nutrition Koshien University
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