Antioxidant Activity of a Novel Extract from Bamboo Grass (AHSS) against Ischemia-Reperfusion Injury in Rat Small Intestine(Pharmacology)
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概要
- 論文の詳細を見る
Production of free radical species in cells and body tissues is known to cause many pathological disorders. Therefore, free radical scavengers play an important role in the prevention of various human diseases. Bamboo grass, Sasa senanensis, is a native Japanese plant. Sasa has been used for medicine in Japan for many centuries. In this study, we investigated the antioxidative activity of Absolutely Hemicellulose Senanensis (AHSS), a novel extract from Sasa, In the first part of this study, we found that AHSS has antioxidant activities by the assay using superoxide anion-2-methyl-6-methoxyphenylethynylimidazopyrazynone (MPEC) reaction kit. We then confirmed its antioxidative activity using a rat ischemia and subsequent reperfusion (I/R) injury model. Breakdown of the intestinal wall caused by intestinal I/R was attenuated by pretreatment with AHSS. Moreover, AHSS inhibited the production of lipid peroxide by intestinal I/R. AHSS could be an important source of ingredients for use in functional foods and other applications.
- 公益社団法人日本薬学会の論文
- 2006-11-01
著者
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Iseki Ken
Department Of Cell Science Institute Of Biomedical Sciences Fukushima Medical University School Of M
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ITAGAKI Shirou
Department of Clinical Pharmaceutics & Therapeutics, Graduate School of Pharmaceutical Sciences, Hok
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HIRANO Takeshi
Department of Clinical Pharmaceutics & Therapeutics, Graduate School of Pharmaceutical Sciences, Hok
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Noda Toshihiro
Department Of Clinical Pharmaceutics And Therapeutics Graduate School Of Pharmaceutical Sciences Hok
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Noda Toshihiro
Department Of Civil Engineering Nagoya University
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KUROKAWA Toshimitsu
Department of Clinical Pharmaceutics and Therapeutics, Graduate School of Pharmaceutical Sciences, H
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YAMAJI Toshihiko
Department of Clinical Pharmaceutics & Therapeutics, Graduate School of Pharmaceutics Sciences, Hokk
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NAKATA Chie
Department of Clinical Pharmaceutics & Therapeutics, Graduate School of Pharmaceutics Sciences, Hokk
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Hirano Takeshi
Department Of Anatomy University Of Occupational And Environmental Health School Of Medicine
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Nakata Chie
Department Of Clinical Pharmaceutics & Therapeutics Graduate School Of Pharmaceutics Sciences Ho
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Yamaji Toshihiko
Department Of Clinical Pharmaceutics & Therapeutics Graduate School Of Pharmaceutics Sciences Ho
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Kurokawa Toshimitsu
Department Of Clinical Pharmaceutics & Therapeutics Graduate School Of Pharmaceutics Sciences Ho
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Iseki Ken
北海道大学医学部附属病院 薬剤
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Itagaki Shirou
Lab. Of Clinical Pharmaceutics & Therapeutics Div. Of Pharmasciences Fac. Of Pharmaceutical Sciences Hokkaido Univ.
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Iseki Ken
Department Of Clinical Pharmaceutics & Therapeutics Graduate School Of Pharmaceutical Sciences Hokkaido University
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