Altered Alpha-1-acid Glycoprotein Concentration and Free Fraction of Disopyramide in Patients with Heart Disease.
スポンサーリンク
概要
- 論文の詳細を見る
Alpha-1-acid glycoprotein (AAG) concentration and protein binding of disopyramide (DSP) in serum were measured in patients with heart disease. An increase in AAG (121±45mg/dl, mean±SD) was fbund in padents with heart failure as compared with healthy controls (73±14) and with cardiac patients without heart failure (78±12). The free fraction of DSP (0.35±0.12) was decreased in patients with heart failure as compared with control (0.56±0.11) and with patients without heart failure (0.47±0.15). The values of the heart failure patients returned to the level of cardiac patients with out heart failure (89±23 mg/dl and 0.48±0.07) with recovery from the decompensated stage. These findings suggest that the free concentration of DSP should be monitored frequently in cardiac patients, especially in patients with congestive heart failure.
- 一般社団法人 日本臨床薬理学会の論文
著者
-
Iseki Ken
Department Of Cell Science Institute Of Biomedical Sciences Fukushima Medical University School Of M
-
Kishino Satoshi
Department Of Medication Use Analysis And Clinical Research Meiji Pharmaceutical University
-
Kitabatake Akira
Department Of Cardicvascular Medicine Hokkaidou University
-
Nomura Akikazu
Department Of Cardiovascular Medicine Hokkaido University School Of Medicine
-
Kitabatake Akira
Department of Cardiovascular Medicine, Hokkaido University School of Medicine
-
Miyazaki Katsumi
Department of Biology, Keio University
-
KISHINO Satoshi
Department of Pharmacy, Hokkaido University Hospital
-
S.DI Zhai
Department of Pharmacy, Hokkaido University Hospital
関連論文
- 1 Pharmacogenomics of β-blocker Therapy in Chronic Heart Failure(New Approaches to Heart Failure-from Pharmacogenomics to Drug Development, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Which is most Beneficial for Preserving Cardiac Function and Coronary Microvasculaturein DCM, ACE-I, ARB or Two in Combination? (Cardiac Hypertrophy/Cardiomyopathy 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Eplerenone Prevents Cardiac Fibrosis through the Inhibition of OPN Expression (Cardiac Hypertrophy, Basic (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Osteopontin is Essential for Angiotensin II-Induced Cardiac Fibrosis(Heart Failure, Basic 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- A Newly Developed Angiotensin II Type 1 Receptor Antagonist, CS866, Promotes Regression of Cardiac Hypertrophy by Reducing Integrin β_1 Expression
- Angiogenesis Is Altered by Angiotensin Type 1 Receptor Blockade in Cardiomyopathic Hamster Hearts
- Angiotensin II Type 2 Receptor Expression Affects Remodeling after Myocardial Infarction in Mice
- Complete Freund's Adjuvant Can Activate TLR2 and Suppress Cardiac Necrosis in Cardiomyopathic Heart
- Blockade of T-cell costimulatory signals using adenovirus vectors attenuates experimental autoimmune myocarditis through the induction of antigen-specific T-cell anergy
- The Chronic Effect of Amlodipine on Cardiac Remodeling in Cardiomyopathic Hamster Hearts
- Complete Freund's Adjuvant can Suppress Cardiac Remodeling in Cardiomyopathic Heart, and Induce Pulmonary Granulomas
- Coronary microvasculature is related with cardiac remodeling in cardiomyopathic hearts
- Development of Atherosclerosis in Osteopontin Transgenic Mice
- Immunosuppressive Therapy in Refractory Heart Failure : Blockade of T Cell Costimulatory Signals
- Role of Microvasculature in Cardiac Remodeling Process
- Prognosis and Prognostic Factors in Patients With Idiopathic Dilated Cardiomyopathy in Japan : Results From a Nationwide Study
- Coronary Disease Morphology and Distribution Determined by Quantitative Angiography and Intravascular Ultrasound : Re-Evaluation in a Cooperative Multicenter Intravascular Ultrasound Study (COMIUS)
- Comparisons of the Skeletal Muscle Metabolic Abnormalities in the Arm and Leg Muscles of Patients With Chronic Heart Failure
- PE-381 Exposure to Pressure Stimulus Enhances Aerobic Metabolism in L6 Cultured Myocytes(Exercise Test/Cardiac Rehabilitation 7 (IHD) : PE65)(Poster Session (English))
- Optimal Weight Reduction Pace to Improve Cardiovascular Risks and C-Reactive Protein Levels
- Exercise Training and Weight Reduction Decreased C-Reactive Protein Levels in Overweight Women
- Cross-sectional study of exercise habit and cardiovascular risk factors in a general population
- Differential response of skeletal muscle sympathetic nerve activity and heart rate to alteration in arterial oxygenation
- The relationship between lactate-transport and Monocarboxylate transporter1 (MCT1) in red blood cell in Normal subjects (NL) and patients with CHF
- Quantitative determination of individual teicoplanin components in human plasma and cerebrospinal fluid by high-performance liquid chromatography with electrochemical detection
- Evaluation of Effects of Polymorphism for Metabolic Enzymes on Pharmacokinetics of Carvedilol by Population Pharmacokinetic Analysis(Biopharmacy)
- OJ-426 Enhanced Temporal and Spatial Cycle Length Variability during Ventricular Fibrillation in Hypertrophic Cardiomyopathy(ECG/Body Surface Potential Mapping/Holter 6 (A) : OJ52)(Oral Presentation (Japanese))
- Increased cycle length variability during ventricular fibrillation : a novel predictor of arrhythmia recurrence
- Altered repolarization dynamics during premature stimulation in Brugada syndrome with inducible ventricular fibrillation
- Prevalence and Clinical Characteristics of Patients With Atrial Fibrillation : Analysis of 20,000 Cases in Japan
- The Efficacy of Radiofrequency Catheter Ablation for the Treatment of Ventricular Tachycardia Associated With Cardiomyopathy
- A Case of Adenosine-Sensitive Ventricular Tachycardia in a Very Elderly Male
- A Case of Familial Ventricular Tachycardia
- Norepinephrine Disrupts Cytoskeletal Framework of Microtubules in Rat Hearts : COMPENSATORY MECHANISMS AND THEIR LIMITATIONS IN HEART FAILURE
- OE-315 Salutary Effects of Attenuation of Angiotensin II Mediated JNK Signaling on Coronary Perivascular Fibrosis Associated With Insulin Resistance and Obesity(Diabetes/Obesity 2 (H) : OE40)(Oral Presentation (English))
- Natural Killer T Cells Accelerate Atherogenesis in Mice
- Up-Regulation of Plasminogen Activator Inhibitor-1 in HepG2 Cells by Interleukin (IL)-1 β and IL-6 and Its Attenuation by HMGCoA Reductase Inhibitor
- Up-Regulation of Plasminogen Activator Ihibitor-1 Production by Hepatocyte Growth Factar in Liver Cells and Its Potential Clinical Implications for Atherothrombosis
- Angiotensin Converting Enzyme (ACE) Inhibition Attenuates Hypofibrinolysis and Reduces Cardiac Perivascular Fibrosis during Development of Diabetic Cardiomyopathy in Obese Mice
- Induction of Plasminogen Activator Inhibitor-1 in Endothelial Cells by Basic Fibroblast Growth Factor and its Modulation by Fibric Acid
- Hypofibrinolysis Downregulates Coronary Capillary Network Remodeling in Aged Obese Diabetic Rats : Implications for Increased Myocardial Vulnerability to Ischemia in Diabetes
- Proinflammatory Cytokines, lnterleukin-1 and -6, and HMGCoA Reductase Inhibitor Up-regulate Plasminogen Activator Inhibitor-1 Production in a Human Liver Cell Line
- Induction of Tissue Factor in Human Endothelial Cells by Basic Fibroblast Growth Factor and its Modulation by Fibric Acid
- Novel Polyethylene Glycol Conjugated S-Nitrosylated Hemoglobin Potently Inhibits Platelet Activation and Adhesion to Artificial Surfaces : Therapeutic Implications for Platelet-Rich Thrombus
- Critical Role of Rho-Associated Protein Kinase and Genistein Sensitive Pathways for Plasminogen Activator Inhibitor-1 Expression in Adipocytes
- Reduced scavenger receptor activity in macrophages from atherosclerosis-resistant strain of mice
- Diminished Left Ventricular Function and Coronary Perivascular Fibrosis Associated with Insulin Resistance do not Require Insulin Receptor Substarte-1 Mediated Signaling
- Augmented phagocytosis and morphological changes by allograft inflammatory factor-1 in activated macrophages : Implications for transplant vasculopathy and atherosclerosis
- Effects of hemoglobin derivatives on the liver microcirculation system ; evaluation of the s-nitroso-polyethylene glycol modified hemoglobin as an artificial oxygen carrier
- Coronary Capillary Remodeling in Non-Insulin-Dependent Diabetic Rats: Amelioration by Inhibition of Angiotensin Converting Enzyme and Its Potential Clinical Implications
- IS064 Angiotensin Converting Enzyme (ACE) Inhibitor Attenuates Microvascular Remodeling During the Development of Diabetic Cardiomyopathy in Genetically Obese Mice
- RT-PCR ANALYSIS OF TYPEL ANGIOTENSIN-II RECEPTOR WITH RELATION TO THE HUMAN HEART
- Effects of Angiotensin-Converting Enzyme Inhibition and Angiotensin II Type 1 Receptor Blockade on β-Adrenoceptor Signaling in Heart Failure
- Estrogen Upregulates Acetylcholine-lnduced EDHF-Mediated Relaxation via Connexin43, Whereas Inhibits EDRF-Mediated One in the Female Rat Mesenteric Artery
- Higher serum Tenascin-C levels reflect the severity of heart failure, left ventricular dysfunction and remodeling in patients with dilated cardiomyopathy
- An SCN5A Mutation Associated With Idiopathic Ventricular Fibrillation Alters The Na^+ Channel Pore Structure And Responses To Antiarrhythmic Drugs
- The Role of Osteopontin in the Development of Granulomatous Lesions in Lung
- Angiotensin-converting enzyme gene polymorphism in Japanese patients with hypertrophic cardiomyopathy.
- Transepithelial Transport of Telmisartan in Caco-2 Monolayers(Pharmacology)
- Transport Mechanism for L-Lactic Acid in Human Myocytes Using Human Prototypic Embryonal Rhabdomyosarcoma Cell Line (RD Cells)(Pharmacology)
- Characterization of Secretory Intestinal Transport of Phenolsulfonphthalein
- Mechanism of L-lactic Acid Transport in L6 Skeletal Muscle Cells
- Comparison of the Disposition Behavior of Organic anions in an Animal Model for Wilson's Disease (Long-Evans Cinnamon rats) with that in Normal Long-Evans Agouti rats
- Mechanism of Active Secretion of Phenolsulfonphthalein in the Liver via Mrp2 (abcc2), an Organic Anion Transporter
- Single-step isolation method for six glycoforms of human α_1-acid glycoprotein by hydroxylapatite chromatography and study of their binding capacities for disopyramide
- Hypofibrinolysis and Increased Metalloproteinase Expression Associated with Coronary Vasculopathy in NIDDM : Primary Role of Angiotensin II Type 1 Receptor
- Activation of Angiotensin II Type 1 Receptor with Angiotensin II Increases Coronary VEGF Expression via an AGEs-HIF-1α Pathway in NIDDM
- Estrogen Mediates Flow-Preserving Neurprotection via Its Angiogenic Action and Sustained NO Production in Middle-Aged Female Rat Brain
- Decrease in Estrogen by Aging Renders Myocardium Ischemic and Estrogen Replacement May Not Fully Protect Heart in Female Rats
- Microangiopathy with dysregulation of angiogenic and apoptotic factors in penile vascular tissues in diabetes mellitus
- Regulation of microvascular angiogenesis by estrogen in the heart of middle-aged female rats
- Differential distribution of angiotensin II receptors in coronary microvasculature in diabetic heart : the potential clinical significance
- Separation methods for glycoprotein analysis and preparation
- Comparison of Cilostazol and Ticlopidine Coadministered with Aspirin for Long-Term Efficacy and Safety after Coronary Stenting ; a Meta-Analysis
- Purification method for α-1-acid glycoprotein with subsequent high-performance liquid chromatographic determination of monosaccharides in plasma of healthy subjects and patients with renal insufficiency
- A Simple Method for the Simulation of Unbound Serum Disopyramide Concentration in Patients
- Plasma concentration of micafungin in patients with hematologic malignancies
- Life-Style Related Factors and Idiopathic Dilated Cardiomyopathy : A Case-Control Study Using Pooled Controls
- Usefulness of Left Parasternal Approach for the Continuous-Wave Doppler Measurement of Left Ventricular Outflow Tract Pressure Gradient in Patients With Hypertrophic Cardiomyopathy
- PJ-283 Early Detection of High Risk Patients for Atherosclerosis in Untreated Hypertensive Patients(Atherosclerosis, Clinical 3 (IHD) : PJ48)(Poster Session (Japanese))
- PJ-135 Feasibility of the Assessment of Left Ventricular Diastolic Function Using Doppler-Derived Early Diastolic Peak Strain Rate(Echo/Doppler 6 (I) : PJ23)(Poster Session (Japanese))
- PJ-020 Evaluation of Circumferential and Longitudinal Myocardial Contraction Using Tissue Doppler Strain Measurement in Patients with Generalized Left Ventricular Myocardial Impairment(Echo/Doppler 2 (I) : PJ4)(Poster Session (Japanese))
- GM3 synthase gene is a novel biomarker for histological classification and drug sensitivity against epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer
- The Effect of Membrane Surface Potential on the Permeability of Anionic Compounds Across the Apical Membrane in Human Intestinal Epithelial (Caco-2) Cells
- UPTAKE CHARACTERISTICS OF POLYAMINES INTO RAT INTESTINAL BRUSH-BORUER MEMBRANE VESICLES
- MECHANISM OF GASTROINTESTINAL ABSORPTION OF β-LACTAM ANTIBIOTICS : Contribution of Passive Diffusion to the BBM Permeation Process
- Characterization of the Disposition of Lutein after i.v. Administration to Rats(Pharmacology)
- Expression Level of ABCG2 in the Placenta Decreases from the Mid Stage to the End of Gestation
- Uninephrectomy induces progressive glomerulosclerosis and apoptosis in anti-Thy1 glomerulonephritis
- INTESTINAL ABSORPTION OF SEVERAL β-LACTAM ANTIBIOTICS. V.^ EFFECT OF AMINO β-LACTAM ANALOGUES AND DIPEPTIDES ON THE ABSORPTION OF AMINO β-LACTAM ANTIBIOTICS
- INTESTINAL ABSORPTION MECHANISMS OF SEVERAL ZWITTERIONIC β-LACTAM ANTIBIOTICS : ROLE OF BRUSH BORDER MEMBRANE AND BINDING TO F1 FRACTION
- A simple and reliable method for determining plasma concentration of dehydroxymethylepoxyquinomicin by high performance liquid chromatography with mass spectrometry
- TRANSPORT CHARACTERISTICS OF QUATERNARY AMMONIUM COMPOUNDS ACROSS RAT SMALL INTESTINAL BRUSH BORDER MEMBRANE
- INTESTINAL ABSORPTION OF SEVERAL β-LACTAM ANTIBIOTICS. IV. BINDING TO THE VARIOUS COMPONENTS IN THE INTESTINAL MUCOSA OF RAT AND ROLE IN ABSORPTION PROCESS
- Protective effect of lutein on ischemia-reperfusion injury in rat small intestine.
- Antioxidant Activity of a Novel Extract from Bamboo Grass (AHSS) against Ischemia-Reperfusion Injury in Rat Small Intestine(Pharmacology)
- Distribution of micafungin in the tissue fluids of patients with invasive fungal infections
- Survey on the Attitudes of Pharmacy Students in Japan toward Doping and Supplement Intake
- Altered Alpha-1-acid Glycoprotein Concentration and Free Fraction of Disopyramide in Patients with Heart Disease.
- The influence of size, specific gravity, and head position on the swallowing of solid Preparatios