INTESTINAL ABSORPTION OF SEVERAL β-LACTAM ANTIBIOTICS. IV. BINDING TO THE VARIOUS COMPONENTS IN THE INTESTINAL MUCOSA OF RAT AND ROLE IN ABSORPTION PROCESS
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概要
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The binding characteristics of zwitterionic and monobasic β-lactam antibiotics to the components intestinal mucosa of rat was investigated. From the binding experiments using the brush border membrane preparation and the insoluble cellular fractions, there was no correlation between the binding behavior and the absorption characteristics. However, there was a highly significant correlation between the affinity to the soluble F1 fraction and the absorption characteristics of these antibiotics. It was also found that the binding of these antibiotics to the other soluble protein fractions were significantly smaller than that to F1 fraction. It was postulated that the binding properties of these antibiotics to soluble F1 fraction play an important role in the absorption process.
- 公益社団法人日本薬学会の論文
著者
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Kobayashi Michiya
北海道大学医学部附属病院 薬剤
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Iseki Ken
Department Of Cell Science Institute Of Biomedical Sciences Fukushima Medical University School Of M
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Arita Takaichi
Department Of Pharmacy Hokkaido University Hospital:faculty Of Pharmaceutical Sciences Mukogawa Wome
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Arita Takaichi
Department Of Pharmacy Hokkaido University Hospital
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Miyazaki Katsumi
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
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Iseki Ken
北海道大学医学部附属病院 薬剤
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Kobayashi Michiya
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
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