Expression and Role of SNAT3 in the Placenta
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概要
- 論文の詳細を見る
Glutamine is the most versatile amino acid and its plasma concentration is the highest of all amino acid. Many transporters are therefore involved in glutamine uptake or efflux. Glutamine is actively released from the placenta into fetal circulation. In this study, we examined the alteration of transporters that transport glutamine into fetal circulation as gestation progresses. High expression levels of system A and y+L were found in the rat placenta in the late period of pregnancy and the expression levels of these transporters increased as gestation progressed (p < 0.05). On the other hand, the expression of SNAT3, the system N transporter, was detected in the early period of pregnancy and its expression level decreased as gestation progressed (p < 0.05). SNAT3 was also found to be expressed in isolated human primary cytotrophoblast cells and its expression level was decreased by their differentiation into syncytiotrophoblast cells (p < 0.05). Since this regulation is closely related to glutamine synthetase expression, SNAT3 may play a key role in providing glutamine corresponding to glutamine synthetase function in the early period of gestation. This is the first report on the expression of SNAT3 in the placenta in the early stage of pregnancy.
- Elsevier Ltd.の論文
著者
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Kobayashi Michiya
北海道大学医学部附属病院 薬剤
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Iseki Ken
北海道大学医学部附属病院 薬剤
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Itagaki Shirou
Lab. Of Clinical Pharmaceutics & Therapeutics Div. Of Pharmasciences Fac. Of Pharmaceutical Sciences Hokkaido Univ.
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Kobayashi Michiya
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
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Iseki Ken
Department Of Clinical Pharmaceutics & Therapeutics Graduate School Of Pharmaceutical Sciences Hokkaido University
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