INTERACTION OF TERTIARY AMINES AND QUATERNARY AMMONIUM COMPOUNDS WITH GASTROINTESTINAL MUCIN
スポンサーリンク
概要
- 論文の詳細を見る
The binding property of some tertiary amines (chlorpromazine, promethazine and imipramine) and quaternary ammonium compounds (propantheline, mepenzolate and butylscopolamine) for gastric mucin was investigated. All tertiary amines tested bound gastric mucin to varying extents, and the binding of chlorpromazine was especially strong. Moreover, the absorption behaviors of chlorpromazine in rat intestinal loops was significantly inhibited in the presence of gastric mucin. On the contrary, all quaternary ammonium compounds tested did not bind gastric mucin and the absorption of propantheline was not affected in the presence of gastric mucin. These results suggested that gastrointestinal mucin produced a significant effect on the bioavailability of these tertiary amines after oral administration.
- 公益社団法人日本薬学会の論文
著者
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SAITOH Hiroshi
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokka
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Kobayashi Michiya
北海道大学医学部附属病院 薬剤
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MIYAZAKI Katsumi
Department of Pharmacy, Hokkaido University Hospital Sapporo
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ARITA TAKAICHI
Department of Pharmacy, Hokkaido University Hospital
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Arita Takaichi
Department Of Pharmacy Hokkaido University Hospital:faculty Of Pharmaceutical Sciences Mukogawa Wome
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Arita Takaichi
Department Of Pharmacy Hokkaido University Hospital
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Hasegawa Noriko
Departments of Pediatrics and Anatomy, Kyorin University School of Medicine
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Miyazaki Katsumi
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
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Saitoh Hiroshi
北海道大学医学部附属病院 薬剤
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Hasegawa Noriko
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
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KAWAI SHINJI
Department of Pharmacy, Hokkaido University Hospital, School of Medicine, Hokkaido University
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Kawai Shinji
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University:faculty O
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Saitoh Hiroshi
Department Of Pediatrics Nihon University School Of Medicine
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Saitoh Hiroshi
Department Of Material Science And Technology Faculty Of Engineering Niigata University
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KAWAI Shinji
Department of Materials Engineering and Applied Chemistry, Mining College, Akita University
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Miyazaki Katsumi
Department of Biology, Keio University
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