Functional analysis of phenolsulfonphthalein transport system in Long-Evans Cinnamon rats
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概要
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It has been reported that the transport function for organic anions on the kidney is maintained in multidrug resistance-associated protein 2 (Mrp2)-deficient rats. Different from Mrp2-deficient rats, Long-Evans Cinnamon (LEC) rats have impaired urinary excretion of Mrp2-substrate, phenolsulfonphthalein (PSP). PSP is transported by the potential-sensitive urate transport system in rat brush-border membranes. We analyzed the function of PSP transport system in LEC rats. Unlike Long-Evans Agouti (LEA) rats, the initial uptake of PSP and urate into the renal brush-border membrane vesicles of LEC rats were not significantly enhanced in the presence of positive intravesicular potential, suggesting that the potential-sensitive urate transport system is impaired in LEC rats. LEC rats should be useful for elucidating the potential-sensitive urate transport system in rats at the molecular level.
- Elsevierの論文
著者
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Sugawara Mitsuru
北海道大学 薬学研究臨床薬剤学
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Kobayashi Michiya
北海道大学医学部附属病院 薬剤
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Chiba Makoto
Laboratory Of Clinical Pharmaceutics & Therapeutics Division Of Pharmaceutics Faculty Of Pharmac
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Iseki Ken
北海道大学医学部附属病院 薬剤
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Itagaki Shirou
Lab. Of Clinical Pharmaceutics & Therapeutics Div. Of Pharmasciences Fac. Of Pharmaceutical Sciences Hokkaido Univ.
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Kobayashi Michiya
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
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Iseki Ken
Department Of Clinical Pharmaceutics & Therapeutics Graduate School Of Pharmaceutical Sciences Hokkaido University
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