Post-Transcriptional Regulation of Breast Cancer Resistance Protein after Intestinal Ischemia-Reperfusion(Pharmacology)
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概要
- 論文の詳細を見る
Breast cancer resistance protein (BCRP), the product of the ABCG2 gene, is a recently identified ATP binding cassette half-transporter. BCRP is expressed in a variety of tumor cells and many normal human tissues. In the small intestine, BCRP can limit the influx and facilitate the efflux to prevent intracellular accumulation of BCRP substrates. Ischemia-reperfusion (I/R) induces the release of reactive oxygen species, and organs are severely damaged by I/R. It has been shown that the expression of transporters was altered in the organ after I/R. The present study was undertaken to clarify the expression of BCRP after intestinal I/R. We showed that the expression level of Bcrp was significantly decreased at 1 h after I/R. Bcrp mRNA level was not altered at 1 h after I/R. These results suggest that Bcrp expression was regulated by a post-transcriptional regulation mechanism after intestinal I/R. Bcrp mRNA level was increased at 24 h after I/R, and the expression level of Bcrp protein was of the same level or slightly increased compared with sham operated-rats. Bcrp was slightly located at the intestinal membrane at 24 h after intestinal I/R. These results suggested that Bcrp was not translocated to the intestinal membrane after intestinal I/R. There is little information on post-transcriptional regulation compared with information on transcriptional regulation. In this study, it was shown that Bcrp expression is regulated by post-transcriptional regulation after intestinal I/R. These results of this study may provide important information for further studies aimed at revealing the biological function of Bcrp.
- 社団法人日本薬学会の論文
- 2008-05-01
著者
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Kobayashi Masaki
Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmace
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Itagaki Shirou
Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmace
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Iseki Ken
Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmace
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Ogura Jiro
Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmace
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Kobayashi Michiya
北海道大学医学部附属病院 薬剤
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HIRANO Takeshi
Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmace
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Iseki Ken
北海道大学医学部附属病院 薬剤
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Itagaki Shirou
Lab. Of Clinical Pharmaceutics & Therapeutics Div. Of Pharmasciences Fac. Of Pharmaceutical Sciences Hokkaido Univ.
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Kobayashi Michiya
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
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Iseki Ken
Department Of Clinical Pharmaceutics & Therapeutics Graduate School Of Pharmaceutical Sciences Hokkaido University
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Kobayashi Masaki
Laboratory I Nano Process Technology Department, Corporate Reseach and Development, Laboratories Research and Development Group, Pioneer Corporation, 1-1, Fujimi 6 chome, Tsurugashima-shi, Saitama 350-2288, Japan
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