Multidrug Resistance Protein 2 Implicates Anticancer Drug-Resistance to Sorafenib
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概要
- 論文の詳細を見る
Sorafenib and sunitinib is a small molecule inhibitor of certain receptor tyrosine kinases, and have improved outcomes for patients with advanced renal cell carcinoma. Inhibitory concentration of 50% cell growth of sorafenib significantly rose to 6.4-fold in a multidrug resistance protein 2 (MRP2) transfected cell line versus control cell line. The concentration of sorafenib was significantly decreased to 74% of control cells after 3 h treatment. In contrast, a tyrosine kinase inhibitor sunitinib did not show alteration of inhibitory concentration of 50% cell growth and accumulation into the cells of MRP2 transfected cells. The present study suggest that sorafenib is a substrate for MRP2, suggesting that MRP2 may implicate drug resistance to sorafenib.
著者
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Iseki Ken
Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmace
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Maeda Hiroshi
Department of Urology, Shinko Clinic
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Shibayama Yoshihiko
Education Research Center for Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Hokkaido Univer
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Ikeda Ryuji
Department Of Clinical Pharmacy And Pharmacology Graduate School Of Medical And Dental Sciences Kago
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Yamada Katsushi
Department Of Clinical Pharmacology Faculty Of Medicine Kagoshima University
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Sugawara Mitsuru
Education Res. Center For Clinical Pharmacy Graduate School Of Pharmaceutical Sciences Hokkaido Univ
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Takeda Yasuo
Department Of Cardiac Surgery Kyusyu University School Of Medicine
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Nakano Kou
Department of Pharmacy, Central Hospital Tenyoukai
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Taguchi Miyuki
Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Ka
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Maeda Hiroshi
Department Of Urology Kurashiki Central Hospital
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Maeda Hiroshi
Department Of Applied Molecular Biology And Biochemistry Tokyo University Of Agriculture And Technol
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Maeda Hiroshi
Department Of Advanced Materials Science And Engineering Graduate School Of Engineering Yamaguchi Un
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Takeda Yasuo
Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University
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Maeda Hiroshi
Department of Pharmacy, Kagoshima City Hospital
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Ikeda Ryuji
Department of Clinical Pharmacy and Pharmacology Graduate School of Medical and Dental Sciences
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