Synthetic Studies of the 18-Membered Antitumor Macrolide, Tedanolide. 3. Stereocontrolled Synthesis of the C1-C12 Part via a Synthesis of the C1-C7 Fragment by a Mismatched but Efficient Sharpless Dihydroxylation and Its Coupling with the C8-C11 Fragment
スポンサーリンク
概要
- 論文の詳細を見る
The C1-C12 part (4) of tedanolide (1) was synthesized starting from methyl (R)-3-hydroxy-2-methylpropionate (11a) via a coupling between the C1-C7 aldehyde (6) and the C8-C11 iodoalkene (7a). For a synthesis of 6,a mismatched but highly efficient Sharpless dihydroxylation of the α, β-unsaturated ester (15) with AD-mix-α was successfully applied. Compound 7a was synthesized using hydrozirconation to the alkyne (32).
- 公益社団法人日本薬学会の論文
- 1999-03-15
著者
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Mori Masao
Faculty Of Hospital Pharmacy Saga Medical School
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Maeda Hiroshi
Department of Urology, Shinko Clinic
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Yonemitsu O
Hokkaido Univ. Sapporo Jpn
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Mori M
Department Of Pharmacy Saga University Hospital
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Mori M
Faculty Of Hospital Pharmacy Saga Medical School
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Mori M
The Institute Of Physical And Chemical Research (riken)
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Nakajima Noriyuki
Biotechno-logy Research Center, Toyama Prefectural University
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YONEMITSU Osamu
Department of Chemistry, Okayama University of Science
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Nakajima Noriyuki
Biotechnology Center Toyama Prefectural University
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Nakajima Noriyuki
Biotechno-logy Research Center Toyama Prefectural University
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Zheng B‐z
Okayama Univ. Sci. Okayama Jpn
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Zheng Bao-zhong
Department Of Chemistry Okayama University Of Science
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森 昌斗
Hospital Pharmacy Saga Medical School
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Mori Michiko
Department Of Pathology Sapporo Medical University School Of Medicine
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Matsushima Tomohiro
Faculty Of Pharmaceutical Sciences Hokkaido University
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UENISHI Jun-ichi
Department of Chemistry, Okayama University of Science
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Yonemitsu Osamu
Departmen Of Chemistry Okayama University Of Science
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Nakajima N
Biotechno-logy Research Center Toyama Prefectural University
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Uenishi J
Department Of Chemistry Okayama University Of Science
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Maeda Hiroshi
Department Of Urology Kurashiki Central Hospital
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Maeda Hiroshi
Department Of Experimental Pathology Cancer Institute
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Maeda Hiroshi
Department Of Applied Molecular Biology And Biochemistry Tokyo University Of Agriculture And Technol
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Maeda Hiroshi
Department Of Advanced Materials Science And Engineering Graduate School Of Engineering Yamaguchi Un
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MORI Michiko
Department of Agricultural Chemistry, Faculty of Agriculture, Utsunomiya University
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Uenishi Jun-ichi
Department of Chemistry, Faculty of Science, Okayama University of Science
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