Placental Folate Transport during Pregnancy
スポンサーリンク
概要
- 論文の詳細を見る
The aim of this study was to elucidate the mechanism of folate transport in the placenta over the course of pregnancy. We found that folate receptor α (FRα) and reduced folate carrier (RFC) localized on the apical side of human placental villi. Since folate binding to placental brush-border membrane vesicles (BBMVs) was strongly inhibited by phosphatidylinositol-specific phospholipase C (PI-PLC) treatment, it is possible that FRα, a glycosyl phosphatidylinositol linked glycoprotein, is a candidate for folate uptake from maternal blood to the placenta. Moreover, additional inhibitory effects of thiamine pyrophosphate (TPP) and hemin on folate uptake after PI-PLC treatment suggested that not only FRα but also RFC and heme carrier protein 1 (HCP1) are involved in the folate transport mechanism in the human placenta. It was also found that accumulation of folate after intravenous injection increased with the progress of gestation in the rat placenta and the fetus. Furthermore, increases in the expression levels of mRNA of rFRα, rRFC, and rHCP1 in the rat placenta during pregnancy were observed. These findings suggest that FRα, RFC, and HCP1 are important carriers of folate in the placenta during pregnancy. The results of this study suggest that increases in the expression levels of FRα, RFC, and HCP1 in the placenta play an important role in the response to increased need for folate for the placenta and fetus during development with the progress of gestation.
- 社団法人 日本農芸化学会の論文
著者
-
Kobayashi Masaki
Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmace
-
Itagaki Shirou
Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmace
-
Iseki Ken
Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmace
-
HIRANO Takeshi
Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmace
-
Yasuda Satoru
Laboratory of Clinical Pharmaceutics and Therapeutics, Division of Pharmascience, Faculty of Pharmac
-
Hasui Satoko
Laboratory of Clinical Pharmaceutics and Therapeutics, Division of Pharmascience, Faculty of Pharmac
-
Yamamoto Chiaki
Laboratory of Clinical Pharmaceutics and Therapeutics, Division of Pharmascience, Faculty of Pharmac
-
YOSHIOKA Chihiro
Laboratory of Clinical Pharmaceutics and Therapeutics, Division of Pharmascience, Faculty of Pharmac
関連論文
- Regulation of Monocarboxylate Transporter 1 in Skeletal Muscle Cells by Intracellular Signaling Pathways
- Pharmacokinetics of Oral and Intravenous Administration of Digoxin after Intestinal Ischemia-Reperfusion
- Amiodarone Increases the Accumulation of DEA in a Human Alveolar Epithelium-Derived Cell Line(Pharmacology)
- Post-Transcriptional Regulation of Breast Cancer Resistance Protein after Intestinal Ischemia-Reperfusion(Pharmacology)
- A New Method for Determination of Both Thalidomide Enantiomers Using HPLC Systems(Analytical Biochemistry)
- Contribution of Multidrug Resistance-Associated Protein 2 to Secretory Intestinal Transport of Organic Anions(Pharmacology)
- The Mechanism of Carrier-Mediated Transport of Folates in BeWo Cells: The Involvement of Heme Carrier Protein 1 in Placental Folate Transport
- Down-Regulation of Intestinal Multidrug Resistance-Associated Protein 2 in Long-Evans Cinnamon Rats
- Long-Evans Cinnamon (LEC) ラットにおける有機アニオンの胆汁排出機構
- 小腸におけるアミオダロン代謝物の排出機構
- Placental Folate Transport during Pregnancy
- Electron Beam Recording beyond 200Gbit/in^2 Density for Next Generation Optical Disk Mastering
- Evaluation of the Hemodynamic Impact of Continuous Renal Replacement Therapy in Healthy Dogs
- Nafamostat Mesilate Is Not Appropriate as an Anticoagulant during Continuous Renal Replacement Therapy in Dogs
- Multidrug Resistance Protein 2 Implicates Anticancer Drug-Resistance to Sorafenib
- Placental Folate Transport during Pregnancy
- The Mechanism of Carrier-Mediated Transport of Folates in BeWo Cells : The Involvement of Heme Carrier Protein 1 in Placental Folate Transport
- Regulation of Nitrate Reductase by Non-modifiable Derivatives of PII in the Cells of Synechococcus elongatus Strain PCC 7942
- Practical Electron Beam Recorder for High-Density Optical and Magnetic Disk Mastering
- Effect of 5-Fluorouracil Treatment on SN-38 Absorption from Intestine in Rats
- Electron Beam Recording beyond 200 Gbit/in2 Density for Next Generation Optical Disk Mastering
- Regulation of the Expression and Activity of Glucose and Lactic Acid Metabolism-Related Genes by Protein Kinase C in Skeletal Muscle Cells