Nafamostat Mesilate Is Not Appropriate as an Anticoagulant during Continuous Renal Replacement Therapy in Dogs
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概要
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We performed continuous renal replacement therapy (CRRT) in clinically healthy dogs (n=7) to evaluate the utility of nafamostat mesilate (NM) as an anticoagulant. In 3 of the 7 dogs, CRRT had to be discontinued before the target duration due to coagulation in the extracorporeal circuit, into which NM was administered constantly at the rate of 2.06.0 mg/kg per hour. The rate of administration of NM was greater than the recommended dose of NM in humans. Further, all the dogs suffered vomiting during CRRT with NM infusion. We therefore recommend that NM is not used as an anticoagulant during CRRT in dogs.
著者
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OKAWA Takumi
Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agricultur
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SHIMOKAWA MIYAMA
Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agricultur
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HIRAOKA Hiroko
Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agricultur
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OKUDA Masaru
Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agricultur
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MIZUNO Takuya
Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agricultur
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Minami Koji
Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University
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ITAMOTO Kazuhito
Laboratory of Veterinary Surgery, Faculty of Agriculture, Yamaguchi University
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YOSHIOKA Chihiro
Laboratory of Clinical Pharmaceutics and Therapeutics, Division of Pharmascience, Faculty of Pharmac
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Mizuno Takuya
Laboratories Of Veterinary Internal Medicine Dep. Of Veterinary Medicine Fac. Of Agriculture Yamaguchi Univ. ...
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OKUDA Masaru
Laboratories of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
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OKAWA Takumi
Laboratories of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
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HIRAOKA Hiroko
Laboratories of Veterinary Clinical Pathology, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
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ITAMOTO Kazuhito
Laboratories of Veterinary Clinical Diagnostics, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
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OKAWA Takumi
Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University
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