Establishment of Five Canine Lymphoma Cell Lines and Tumor Formation in a Xenotransplantation Model
スポンサーリンク
概要
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Five novel, canine lymphoma cell lines (Ema, CLC, CLK, Nody-1 and UL-1) were established from dogs suffering from lymphoma and characterized in vitro and in vivo. All cell lines, except CLC, were characterized with T-cell phenotypes, by flow cytometric analysis and polymerase chain reaction for antigen receptor rearrangement. Cell proliferation rates and transcriptional levels of MYC, PTEN, KIT, and FLT3 varied between each cell line. Intraperitoneal xenotransplantation of Ema, CLC, Nody-1 and UL-1 lymphoma cell lines into NOD/SCID mice induced ascites, intraperitoneal tumors and severe infiltration of lymphoma cells into the pancreas and mesentery. Establishment of novel canine lymphoma cell lines with different characteristics is critical for elucidating the pathophysiology of canine lymphoma and improving current therapies.
著者
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Kubo Masahito
Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological
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Hayashi Toshiharu
Laboratory Of Veterinary Pathology Faculty Of Agriculture Yamaguchi University
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SUZUKI Ryoichi
Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agricultur
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UMEKI Saori
Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agricultur
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Tani Kenji
Laboratory Of Molecular Immunoregulation Medicine Branch National Cancer Institute Frederick Cancer
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Mizuno Takuya
Laboratories Of Veterinary Internal Medicine Dep. Of Veterinary Medicine Fac. Of Agriculture Yamaguchi Univ. ...
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OKUDA Masaru
Laboratories of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
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HIRAOKA Hiroko
Laboratories of Veterinary Clinical Pathology, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
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OKAMURA Yasuhiko
Laboratory of Veterinary Surgery, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, 3–18–8 Ueda, Morioka, Iwate 020–8550, Japan
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EMA Yasuo
Laboratory of Veterinary Internal Medicine, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan
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YAMAZAKI Jumpei
Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, U.S.A.
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TSUJIMOTO Hajime
Laboratory of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan
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KUBO Masahito
Laboratory of Veterinary Pathology, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan
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HIRAOKA Hiroko
Laboratory of Veterinary Clinical Pathology, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan
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UMEKI Saori
Laboratory of Veterinary Internal Medicine, The United Graduate School of Veterinary Science, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan
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