Cloning of the Feline GADD45 cDNA and Analysis of its Mutation in Feline Lymphoma Cell Lines
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概要
- 論文の詳細を見る
Growth arrest and DNA damage-inducible protein 45 (GADD45) plays an important role in suppressing multistep carcinogenesis. In this report, we describe the isolation of the complete wild-type feline GADD45 cDNA from feline tissues. Expression of feline GADD45 mRNA was detected in the liver, spleen, kidney, lung, and testis. The predicted amino acid sequences encoded by the full-length feline GADD45 cDNA display sequence homology with those from other vertebrates, and as in the case of human GADD45, cell growth suppression was observed by ectopic expression of feline GADD45. However, no mutations were detected by sequence analysis of feline GADD45 in several feline lymphoma cell lines, indicating that the GADD45 mutation might be uncommon in feline oncogenesis.
- 公益社団法人 日本獣医学会の論文
著者
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Kaneko Naoki
Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University
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NAKAICHI Munekazu
Laboratory of Veterinary Radiology, Faculty of Agriculture, Yamaguchi University
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Inokuma Hisashi
Laboratory Of Veterinary Internal Medicine Faculty Of Agriculture Yamaguchi University
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Mizuno Takuya
Laboratories Of Veterinary Internal Medicine Dep. Of Veterinary Medicine Fac. Of Agriculture Yamaguchi Univ. ...
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OKUDA Masaru
Laboratories of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
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HIRAOKA Hiroko
Laboratories of Veterinary Clinical Pathology, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
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ITAMOTO Kazuhito
Laboratories of Veterinary Clinical Diagnostics, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
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ITAMOTO Kazuhito
Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University
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WATANABE Malaika
Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University
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OIKAWA Tatsuo
Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University
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HIRAOKA Hiroko
Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University
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NAKAICHI Munekazu
Laboratory of Veterinary Surgery, Faculty of Agriculture, Yamaguchi University
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