Nationwide Survey of Leptospira Antibodies in Dogs in Japan: Results from Microscopic Agglutination Test and Enzyme-Linked Immunosorbent Assay
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概要
- 論文の詳細を見る
Leptospirosis is an infectious disease caused by Leptospira interrogans sensu lato and is common in both humans and animals. In the present study, serum samples were collected from 801 dogs across all 47 prefectures in Japan, and evaluated with a microscopic agglutination test (MAT), using 5 major L. interrogans serovars (Icterohaemorrhagiae, Canicola, Autumnalis, Hebdomadis, and Australis) as antigens, and an enzyme-linked immunosorbent assay (ELISA) using recombinant OmpL1 protein as the antigen. Across all dogs tested, 217 (27.0%) and 29 (3.6%) were MAT- and ELISA-positive, respectively. However, evidence strongly suggests that MAT also detected antibodies produced by vaccination. Of 243 dogs never inoculated with any canine vaccine, 41 (16.9%) from 23 prefectures were MAT and/or ELISA positive. The most commonly detected serovar was Icterohaemorrhagiae (22 dogs, 19 prefectures). Our results suggest that there are dogs with subclinical Leptospira infection throughout Japan. To the best of our knowledge, the present study is the first nationwide survey of Leptospira infection in dogs, and the findings are relevant not only for clinical veterinary medicine but also for public health.
- 社団法人 日本獣医学会の論文
著者
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OKUDA Masaru
Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agricultur
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MIZUNO Takuya
Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agricultur
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IWATA Hiroyuki
Laboratory of Veterinary Hygiene, Faculty of Agriculture, Yamaguchi University
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Wada Yuko
Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University
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ITAMOTO Kazuhito
Laboratory of Veterinary Surgery, Faculty of Agriculture, Yamaguchi University
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UMEKI Saori
Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agricultur
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IWAMOTO Emiko
Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University
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FUJISAKI Yuka
Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University
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Maeda Ken
Laboratory Of Fisheries Biology & Coral Reef Studies Faculty Of Science University Of The Ryukyu
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JONES Miyuki
Fort Dodge K.K
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Mizuno Takuya
Laboratories Of Veterinary Internal Medicine Dep. Of Veterinary Medicine Fac. Of Agriculture Yamaguchi Univ. ...
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OKUDA Masaru
Laboratories of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
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MAEDA Ken
Laboratory of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University
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ITAMOTO Kazuhito
Laboratories of Veterinary Clinical Diagnostics, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
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WADA Yuko
Laboratories of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan
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