Experimental Infection of Japanese Encephalitis Virus in Dogs
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概要
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A previous serosurvey of Japanese encephalitis virus (JEV) among dogs suggested that dogs, and not pigs, are well suited for use as sentinels for assessing the risk of JEV transmission to humans. To examine the clinical symptoms and duration of anti-JEV antibodies in dogs, three dogs were experimentally challenged with JEV. All JEV-infected dogs did not show any clinical signs or abnormal blood tests, except for C-reactive protein. Virus-neutralization titers rapidly increased and were maintained until 70 days postinfection, and neither the virus nor the viral genome was detected in blood. Thus, since dogs live in close proximity to humans as companion animals, they are well suited for use as sentinels for surveying the human risk of JEV infection.
著者
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HAYASHI Toshiharu
Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University
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MORIMOTO Masahiro
Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University
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Hayashi Toshiharu
Laboratory Of Veterinary Pathology Faculty Of Agriculture Yamaguchi University
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SHIMOJIMA Masayuki
Laboratory of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University
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SHIMODA Hiroshi
Laboratory of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University
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TAMARU Seiji
Laboratory of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University
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Maeda Ken
Laboratory Of Fisheries Biology & Coral Reef Studies Faculty Of Science University Of The Ryukyu
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