Enhanced Protection against Heligmosomoides polygyrus in IL-2 Receptor β-Chain Overexpressed Transgenic Mice with Intestinal Mastocytosis

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概要

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• IL-2 receptor β-chain overexpressed transgenic (Tg2Rβ) mice lack NK cells, but the development of other lymphocyte subsets and macrophages remained apparently intact. These mice also represent intestinal mastocytosis. Helminth infection induces various immune responses such as mast cells, goblet cells, eosinophils, and IgE, mediated by Th2 cytokines. IL-4 is also important in the regulation of resistance and susceptibility to Heligmosomoides polygyrus infection. However, there were contradictory results about the relation between resistance to H. polygyrus and intestinal mastocytosis. The present study showed that Tg2Rβ mice suppressed worm fecundity with mastcytosis, and without the increase of the levels of goblet cells, eosinophils, and IgE compared with control mice. These results clearly indicated that mast cells have the ability for protection of H. polygyrus infection. However, additional studies are required to evaluate protective effector mechanisms against H. polygyrus.

著者

• MORIMOTO Masahiro

  Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University

• UTSUMIYA Kyoko

  Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University

関連論文

• Enhanced Protection against Heligmosomoides polygyrus in IL-2 Receptor β-Chain Overexpressed Transgenic Mice with Intestinal Mastocytosis
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