Function of Feline Signaling Lymphocyte Activation Molecule as a Receptor of Canine Distemper Virus

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概要

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• Morbilliviruses use signaling lymphocyte activation molecule (SLAM) as a receptor for their entry to cells. In this study, a complete gene encoding SLAM of a domestic cat was identified. The identity of feline SLAM with canine one was 73%, and feline SLAM formed the same cluster with those of carnivores. Furthermore, feline cell expressing feline SLAM supported growth of canine distemper virus (CDV) as well as that expressing canine one. These results indicated that feline SLAM can function as a receptor for morbilliviruses, and our established feline cells that express feline SLAM might be useful for analysis of morbilliviruses originated from felids.

• 公益社団法人 日本獣医学会の論文

著者

• SHIMODA Hiroshi

  Laboratory of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University

• Suzuki Junko

  Laboratory Of Atmospheric Environment Information Analysis Rish Kyoto University

• Maeda Ken

  Laboratory Of Fisheries Biology & Coral Reef Studies Faculty Of Science University Of The Ryukyu

• Terada Yutaka

  Laboratory Of Pasturing Disease National Institute Of Animal Hearth

• Mizuno Takuya

  Laboratories Of Veterinary Internal Medicine Dep. Of Veterinary Medicine Fac. Of Agriculture Yamaguchi Univ. ...

• NOGUCHI Keita

  Laboratory of Veterinary Microbiology, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan

• SHIMODA Hiroshi

  Laboratory of Veterinary Microbiology, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan

• MIZUNO Takuya

  Laboratory of Veterinary Internal Medicine, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan

• HARA Yuka

  Laboratory of Veterinary Microbiology, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan

• SUZUKI Junko

  Laboratory of Veterinary Microbiology, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan

• MAEDA Ken

  Laboratory of Veterinary Microbiology, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan

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