Transepithelial Transport of Telmisartan in Caco-2 Monolayers(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
Telmisartan is the most recently marketed angiotensin II type 1 receptor antagonist. Drug-drug interactions involving transporters can directly affect the therapeutic safety and efficacy of many important drugs. In clinical practice, telmisartan is coadministered with many kinds of drugs. However, little is known about the contribution of transporters to the intestinal transport of telmisartan. The aim of this study was to determine the transport mechanism of telmisartan across intestinal epithelial cells. In the presence of an inwardly directed proton gradient, the apical-to-basal transport of telmisartan was greater than basal-to-apical transport. Thus, we focused on the uptake mechanism of telmisartan across brush-border membranes. The uptake of telmisartan by Caco-2 cells was shown to be energy- and proton-dependent. Although some monocarboxylates inhibited the uptake of telmisartan, L-lactic acid, which is a typical substrate of the monocarboxylate transporter (MCT) 1-MCT4, did not affect the uptake of telmisartan. Preloading of acetic acid enhanced the uptake of telmisartan, showing a trans-stimulation effect. These results suggest that the carrier-mediated transport system is involved in the uptake of telmisartan by Caco-2 cells and that the apical-localized transport system is similar to MCTs, but not MCT1-MCT4. It is possible that telmisartan reduce the absorption of coadministered drugs by sharing the MCTs. Since MCTs have an important role in the intestinal absorption of pharmacologically active compounds, it is important to be aware of the potential of telmisartan-drug interactions involving MCTs and to act in order to prevent undesirable and harmful consequences.
- 社団法人日本薬学会の論文
- 2005-12-01
著者
-
KOBAYASHI Masaki
Department of Internal Medicine, Tokyo Medical University, Kasumigaura Hospital
-
Kobayashi Michiya
北海道大学医学部附属病院 薬剤
-
TADANO Koji
Department of Pharmacy, Sapporo City General Hospital
-
Iseki Ken
Department Of Clinical Pharmaceutics And Therapeutics Graduate School-of Pharmaceutical Sciences Hok
-
Iseki Ken
Department Of Cell Science Institute Of Biomedical Sciences Fukushima Medical University School Of M
-
GOTO Yoshikazu
Department of Pharmacy, Sapporo City General Hospital
-
ITAGAKI Shirou
Department of Clinical Pharmaceutics & Therapeutics, Graduate School of Pharmaceutical Sciences, Hok
-
UMEDA Shinichiro
Department of Clinical Pharmaceutics & Therapeutics, Graduate School of Pharmaceutical Sciences, Hok
-
HIRANO Takeshi
Department of Clinical Pharmaceutics & Therapeutics, Graduate School of Pharmaceutical Sciences, Hok
-
Kobayashi Masaki
Department Of Internal Medicine Tokyo Medical University Kasumigaura Hospital
-
Goto Yoshikazu
Department Of Pharmacy Sapporo City General Hospital
-
Goto Yoshikazu
Department Of Cardiovascular Surgery Akita Medical Center
-
Tadano Koji
Department Of Pharmacy Sapporo City General Hospital
-
Umeda Shinichiro
Department Of Clinical Pharmaceutics & Therapeutics Graduate School Of Pharmaceutical Sciences H
-
Hirano Takeshi
Department Of Anatomy University Of Occupational And Environmental Health School Of Medicine
-
Iseki Ken
北海道大学医学部附属病院 薬剤
-
Kobayashi Masaki
Department Of Biology School Of Education Waseda University
-
Itagaki Shirou
Lab. Of Clinical Pharmaceutics & Therapeutics Div. Of Pharmasciences Fac. Of Pharmaceutical Sciences Hokkaido Univ.
-
Kobayashi Michiya
Department Of Pharmacy Hokkaido University Hospital School Of Medicine Hokkaido University
-
Iseki Ken
Department Of Clinical Pharmaceutics & Therapeutics Graduate School Of Pharmaceutical Sciences Hokkaido University
-
Kobayashi Masaki
Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Josai University
関連論文
- Regulation of Monocarboxylate Transporter 1 in Skeletal Muscle Cells by Intracellular Signaling Pathways
- Pharmacokinetics of Oral and Intravenous Administration of Digoxin after Intestinal Ischemia-Reperfusion
- Renal pathology of ANCA-related vasculitis : proposal for standardization of pathological diagnosis in Japan
- 腎機能低下時のミコフェノール酸グルクロナイドの胆汁排泄増加が消化管障害の引き金になる
- Clinicopathological study of dialysis patients with lupus nephritis
- ANALYSIS OF OSTEOBLAST SPECIFIC MESSENGER RNA EXPRESSION IN THE REGENERATING SCALE OF GOLDFISH, Carassius auratus
- MOLECULAR CLONING OF cDNAs ENCODING MARKERS IN OSTEOCLASTS, TRAP AND CATHEPSIN K IN GOLDFISH(Endocrinology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- EFFECTS OF MELATONIN ON OSTEOCLAST DIFFERENTIATION INDUCED BY AN INTRAMUSCULAR AUTOTRANSPLANTATION OF THE GOLDFISH SCALE
- Liver X receptor regulates expression of MRP2 but not that of MDR1 and BCRP in the liver
- Amplitude of the s-Wave of Multifocal Electroretinograms Can Indicate Local Retinal Sensitivity in Glaucomatous Eyes
- AMP-activated protein kinase regulates the expression of monocarboxylate transporter 4 in skeletal muscle
- Deoxyspergualin, an immunosuppressant, in patients suffering from nephropathies with crescent formation : an open-label trial to evaluate safety and efficacy
- Expression and Role of SNAT3 in the Placenta
- Amiodarone Increases the Accumulation of DEA in a Human Alveolar Epithelium-Derived Cell Line(Pharmacology)
- Post-Transcriptional Regulation of Breast Cancer Resistance Protein after Intestinal Ischemia-Reperfusion(Pharmacology)
- A New Method for Determination of Both Thalidomide Enantiomers Using HPLC Systems(Analytical Biochemistry)
- Contribution of Multidrug Resistance-Associated Protein 2 to Secretory Intestinal Transport of Organic Anions(Pharmacology)
- Functional analysis of phenolsulfonphthalein transport system in Long-Evans Cinnamon rats
- The Mechanism of Carrier-Mediated Transport of Folates in BeWo Cells: The Involvement of Heme Carrier Protein 1 in Placental Folate Transport
- Down-Regulation of Intestinal Multidrug Resistance-Associated Protein 2 in Long-Evans Cinnamon Rats
- Long-Evans Cinnamon (LEC) ラットにおける有機アニオンの胆汁排出機構
- 小腸におけるアミオダロン代謝物の排出機構
- Purification by p-aminobenzoic acid (PABA)-affinity chromatography and the functional reconstitution of the nateglinide/H+ cotransport system in the rat intestinal brush-border membrane
- Transepithelial Transport of Telmisartan in Caco-2 Monolayers(Pharmacology)
- Transport Mechanism for L-Lactic Acid in Human Myocytes Using Human Prototypic Embryonal Rhabdomyosarcoma Cell Line (RD Cells)(Pharmacology)
- Characterization of Secretory Intestinal Transport of Phenolsulfonphthalein
- Mechanism of L-lactic Acid Transport in L6 Skeletal Muscle Cells
- Comparison of the Disposition Behavior of Organic anions in an Animal Model for Wilson's Disease (Long-Evans Cinnamon rats) with that in Normal Long-Evans Agouti rats
- Mechanism of Active Secretion of Phenolsulfonphthalein in the Liver via Mrp2 (abcc2), an Organic Anion Transporter
- Single-step isolation method for six glycoforms of human α_1-acid glycoprotein by hydroxylapatite chromatography and study of their binding capacities for disopyramide
- Purification method for α-1-acid glycoprotein with subsequent high-performance liquid chromatographic determination of monosaccharides in plasma of healthy subjects and patients with renal insufficiency
- A Simple Method for the Simulation of Unbound Serum Disopyramide Concentration in Patients
- X-ray Magnetic Circular Dichroism and Photoemission Study of the Diluted Ferromagnetic Semiconductor Zn_Cr_xTe
- GM3 synthase gene is a novel biomarker for histological classification and drug sensitivity against epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer
- Synthetic Decarboxylated S-Adenosyl-L-methionine as a Substrate for Aminopropyl Transferases
- Fate of Orally Administered ^15N-LabeIed Polyamines in Rats Bearing Solid Tumors
- Fragmentation of the DNA Repair Enzyme, OGG1, in Mouse Nonparenchymal Liver Cells by Arsenic Compounds
- Detection of a mouse OGG1 fragment during caspase-dependent apoptosis : Oxidative DNA damage and apoptosis
- Sequence Specificity of the 8-Hydroxyguanine Repair Activity in Rat Organs
- Increase in 8-Hydroxyguanine and Its Repair Activity in the Esophagi of Rats Given Long-term Ethanol and Nutrition-deficient Diet
- Analyses of Oxidative DNA Damage and Its Repair Activity in the Livers of 3'-Methyl-4-dimethylaminoazobenzene-treated Rodents
- Inhibition of Nucleolar Function and Morphological Change by Adriamycin Associated with Heat Shock Protein 70 Accumulation
- The Effect of Membrane Surface Potential on the Permeability of Anionic Compounds Across the Apical Membrane in Human Intestinal Epithelial (Caco-2) Cells
- The Transport Mechanism of an Organic Cation, Disopyramide, by Brush-Border Membranes. : Comparison Between Renal Cortex and Small Intestine of the Rat.
- UPTAKE CHARACTERISTICS OF POLYAMINES INTO RAT INTESTINAL BRUSH-BORUER MEMBRANE VESICLES
- MECHANISM OF GASTROINTESTINAL ABSORPTION OF β-LACTAM ANTIBIOTICS : Contribution of Passive Diffusion to the BBM Permeation Process
- Incidence of postoperative ileus after paraaortic lymph node dissection in patients with malignant gynecologic tumors
- Characterization of the Disposition of Lutein after i.v. Administration to Rats(Pharmacology)
- Expression Level of ABCG2 in the Placenta Decreases from the Mid Stage to the End of Gestation
- Zooplankton distribution patterns in relation to the Antarctic Polar Front Zones Recorded by Continuous Plankton Recorder (CPR) during 1999/2000 Kaiyo Maru cruise
- Effects of Starvation on Gonadotropin and Thyrotropin Subunit mRNA Levels and Plasma Hormone Levels in the Male Japanese Quail (Coturnix coturnix japonica)(Endocrinology)
- evidence-based practice guideline for the treatment of chronic kidney disease
- Venous Aneurysm of the Cephalic Vein : Report of a Case
- A Localized Fibrous Tumor(Mesothelioma)in the Mediastinum:Report of a Case
- Tubulointerstitial nephritis and uveitis syndrome associated with hyperthyroidism
- Mass Spectrometric Separation and Determination of N^1,N^-Diacetylspermine in the Urine of Cancer Patients
- THE OPTIMAL MODEL WITH PASSENGER'S SATISFACTION OF RAILROAD
- Analysis of T-cell receptor usage in myeloperoxidase-antineutrophil cytoplasmic antibody-associated renal vasculitis
- Effects of Calcium Phosphate Cement on the Peripheral Nerve Fibers
- cDNA Cloning of Inducer Reactive Protein in Adult T-Cell Leukemia Cells by Applying the Fuzzy Set Cloning Theory for Sequencing Defuzzification
- Cold Model Experiments of Gas Removal from Molten Metal by an Irradiation of Ultrasonic Waves
- Different Responses Other than the Formation of DNA-adducts between the Livers of Carcinogen-resistant Rats (DRH) and Carcinogen-sensitive Rats (Donryu) to 3'-Methyl-4-dimethylaminoazobenzene Administration
- Effects of Starvation and Refeeding on Gonadotropin and Thyrotropin Subunit mRNAs in Male Japanese Quail(Endocrinology)
- Uninephrectomy induces progressive glomerulosclerosis and apoptosis in anti-Thy1 glomerulonephritis
- Hypoproteinemia Caused by Tricuspid Regurgitation : Report of a Case
- INTESTINAL ABSORPTION OF SEVERAL β-LACTAM ANTIBIOTICS. V.^ EFFECT OF AMINO β-LACTAM ANALOGUES AND DIPEPTIDES ON THE ABSORPTION OF AMINO β-LACTAM ANTIBIOTICS
- INTESTINAL ABSORPTION MECHANISMS OF SEVERAL ZWITTERIONIC β-LACTAM ANTIBIOTICS : ROLE OF BRUSH BORDER MEMBRANE AND BINDING TO F1 FRACTION
- Pleuritis Caused by Campylobacter jejuni subspecies jejuni in a Patient Undergoing Long-Term Hemodialysis
- SEVERAL FINDINGS ON THE MECHANISM OF GASTROINTESTINAL ABSORPTION OF QUATERNARY AMMONIUM COMPOUNDS
- INTERACTION OF TERTIARY AMINES AND QUATERNARY AMMONIUM COMPOUNDS WITH GASTROINTESTINAL MUCIN
- Placental Folate Transport during Pregnancy
- The Mechanism of Carrier-Mediated Transport of Folates in BeWo Cells : The Involvement of Heme Carrier Protein 1 in Placental Folate Transport
- Changes in the s-Wave of Multifocal Electroretinograms in Eyes with Primary Open-Angle Glaucoma
- Intrapericardial Organized Hematoma : A Rare Complication After Open Heart Surgery
- Experimental Study on the Scavenging Effects of Ginsenosides on Oxygen Free Radicals Using Model of Heterotopic Heart Transplantation in Rats
- Effect of Internal Radiative Heat Transfer on Melt/Crystal Interface Shape in Czochralski Growth of Oxide Crystals
- S-II-6. Diagnostic Criteria and Operative Indication of So-called Normal Pressure Hydrocephalus by Radioisotope Cisternography and Ventriculography
- Mizoribine reduces serum KL-6 levels in ANCA-associated vasculitis
- TRANSPORT CHARACTERISTICS OF QUATERNARY AMMONIUM COMPOUNDS ACROSS RAT SMALL INTESTINAL BRUSH BORDER MEMBRANE
- INTESTINAL ABSORPTION OF SEVERAL β-LACTAM ANTIBIOTICS. IV. BINDING TO THE VARIOUS COMPONENTS IN THE INTESTINAL MUCOSA OF RAT AND ROLE IN ABSORPTION PROCESS
- Preparation of Disopyramide Suppository and Its Phamaceutical Evaluation.
- Protective effect of lutein on ischemia-reperfusion injury in rat small intestine.
- Antioxidant Activity of a Novel Extract from Bamboo Grass (AHSS) against Ischemia-Reperfusion Injury in Rat Small Intestine(Pharmacology)
- Changes in Protein Secretory Patterns during the Development of the Rat Epididymis : Reproductive Biology
- Repair System of 7,8-Dihydro-8-Oxoguanine as a Defense Line against Carcinogenesis
- Methicillin-resistant Staphylococcus-aureus-associated glomerulonephritis on the decline : decreased incidence since the 1990s
- Role of interactions among endothelin-1, CD44, and hyaluronic acid in mouse mesangial cell proliferation
- Effects of acute low-dose ethanol on inflammatory reactions to endotoxin-induced shock in rats
- A rapid and sensitive LC/ESI-MS/MS method for quantitative analysis of docetaxel in human plasma and its application to a pharmacokinetic study.
- A full validated hydrophilic interaction liquid chromatography-tandem mass spectrometric method for the quantification of oxaliplatin in human plasma ultrafiltrates.
- Study on Mechanism of Ultrasonic Fluorescence Modulation in Light Scattering Medium Based on Diffusion Approximation with Varying Refractive Index
- Optical Visualization of Ultrasound Pressure Fields in Turbid Media Based on Coherent Detection Imaging Technique
- Protective Effect of Soy Isoflavone Genistein on Ischemia-Reperfusion in the Rat Small Intestine
- The Relationship between the Plasma Concentration of Bepridil and Its Efficacy in the Treatment of Atrial Fibrillation in Japanese Patients
- X-ray Magnetic Circular Dichroism Investigations of the Origin of Room Temperature Ferromagnetism in Fe-Doped ZnO Nanoparticles
- Soft X-ray Absorption and Photoemission Studies of Ferromagnetic Mn-Implanted 3C-SiC
- Survey on the Attitudes of Pharmacy Students in Japan toward Doping and Supplement Intake
- Altered Alpha-1-acid Glycoprotein Concentration and Free Fraction of Disopyramide in Patients with Heart Disease.
- Detection of a smaller, 32-kDa 8-oxoguanine DNA glycosylase 1 in 3'-methyl-4-dimethylaminoazobenzene-treated mouse liver
- The influence of size, specific gravity, and head position on the swallowing of solid Preparatios