Expression Level of ABCG2 in the Placenta Decreases from the Mid Stage to the End of Gestation
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概要
- 論文の詳細を見る
The aim of this study was to elucidate the expression pattern of ABCG2 in the placenta from the mid stage to the end of gestation. rABCG2 expression was investigated in rats on the 14th gestation day (gd) and the 20th gd. Expression of the rABCG2 gene and expression of rABCG2 protein in the placenta were detected on gd 14 by RT-PCR and Western blot analysis respectively. The expression level of rABCG2 on gd 20 was less than that on gd 14. We investigated whether progesterone, secreted from the placenta, regulates the expression of ABCG2 in BeWo cells. Expression levels of the ABCG2 gene and protein in BeWo cells were decreased by progesterone treatment. We conclude that progesterone plays a role in reduction in the expression level of ABCG2 in the placenta with the advance of gestation from the mid stage to the end of gestation.
- 社団法人 日本農芸化学会の論文
- 2005-10-23
著者
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Iseki Ken
Department Of Clinical Pharmaceutics And Therapeutics Graduate School-of Pharmaceutical Sciences Hok
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Iseki Ken
Department Of Cell Science Institute Of Biomedical Sciences Fukushima Medical University School Of M
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ITAGAKI Shirou
Department of Clinical Pharmaceutics & Therapeutics, Graduate School of Pharmaceutical Sciences, Hok
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HIRANO Takeshi
Department of Clinical Pharmaceutics & Therapeutics, Graduate School of Pharmaceutical Sciences, Hok
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YASUDA Satoru
Department of Clinical Pharmaceutics and Therapeutics, Graduate School of Pharmaceutical Sciences, H
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Hirano Takeshi
Department Of Anatomy University Of Occupational And Environmental Health School Of Medicine
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Iseki Ken
北海道大学医学部附属病院 薬剤
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Itagaki Shirou
Lab. Of Clinical Pharmaceutics & Therapeutics Div. Of Pharmasciences Fac. Of Pharmaceutical Sciences Hokkaido Univ.
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Iseki Ken
Department Of Clinical Pharmaceutics & Therapeutics Graduate School Of Pharmaceutical Sciences Hokkaido University
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