Cyclosporin A therapy and drug monitoring by HPLC following renal transplantation.
スポンサーリンク
概要
- 論文の詳細を見る
We describe cyclosporin A therapy and drug monitoring by HPLC and RIA following renal transplantation or in a patient with Bechet's disease. There was considerable variation in the relationship between HPLC and RIA measurements. The concentrations of cyclosporin A measured by HPLC were invariably less than those measured by RIA. In concentration-time curves of cyclosporin A after dosing, the peak concentrations were observed at 1 to 2 hours in all patients. During the clinical course of patients after renal transplantation, there were considerable variations in RIA measurements, and attempts were made to achieve a concentration of from 100 to 300 ng/ ml by HPLC. During the study period, no renal toxicity or rejection episodes were observed in any patient.
- 一般社団法人 日本臨床薬理学会の論文
著者
-
YUHKI Yoshimitsu
Department of Pharmacy, Sapporo City General Hospital
-
TAKAHASHI Yasushi
Department of Pharmacy, Sapporo City General Hospital
-
Tadano Kohji
Department Of Pharmacy Sapporo City General Hospital
-
Hirano Tetsuo
Department Of Kidney Transplant Surgery Sapporo City General Hospital
-
Arita Takaichi
Department Of Pharmacy Hokkaido University Hospital
-
Yuhki Yoshimitsu
Department Of Pharmacy Sapporo City General Hospital
-
Takahashi Yasushi
Department Of Pediatrics Akita University School Of Medicine
-
Miyazaki Katsumi
Department of Biology, Keio University
-
MIYAZAKI Katsumi
Department of Renal Transplantation, Sapporo City General Hospital
-
KOKUBUN Kunio
Department of Pharmacy, Sapporo City General Hospital
関連論文
- ^Tc-DTPA dynamic SPECT and CT volumetry for measuring split renal function in live kidney donors
- Characterization of Secretory Intestinal Transport of Phenolsulfonphthalein
- Comparison of the Disposition Behavior of Organic anions in an Animal Model for Wilson's Disease (Long-Evans Cinnamon rats) with that in Normal Long-Evans Agouti rats
- Mechanism of Active Secretion of Phenolsulfonphthalein in the Liver via Mrp2 (abcc2), an Organic Anion Transporter
- Single-step isolation method for six glycoforms of human α_1-acid glycoprotein by hydroxylapatite chromatography and study of their binding capacities for disopyramide
- HYDROLYSES OF DRUGS IN ACIDIC MEDIA-REVERSIBLE RING-OPENING REACTIONS OF BENZODIAZEPINE ANTIANXIETY AGENTS
- Purification method for α-1-acid glycoprotein with subsequent high-performance liquid chromatographic determination of monosaccharides in plasma of healthy subjects and patients with renal insufficiency
- A Simple Method for the Simulation of Unbound Serum Disopyramide Concentration in Patients
- Epididymo-orchitis caused by intravesically instillated bacillus Calmette-Guerin : Genetically proven using a multiplex polymerase chain reaction method
- Intravenous digital subtraction angiography and helical computed tomography in evaluation of living renal donors
- Pre-emptive renal transplantation in children
- Pharmacokinetics and efficacy of low-dose methotrexate in patients with rheumatoid arthritis
- Inhibitory Effects of Basic Drugs on the Sodium-Dependent Transport of L-Alanine via System B^0 in the Small Intestine
- The Effect of Membrane Surface Potential on the Permeability of Anionic Compounds Across the Apical Membrane in Human Intestinal Epithelial (Caco-2) Cells
- MECHANISM OF GASTROINTESTINAL ABSORPTION OF β-LACTAM ANTIBIOTICS : Contribution of Passive Diffusion to the BBM Permeation Process
- InVitro Selection of Variants of Herpes Simplex Virus Type 1 Which Differ in Cytopathic Chenges
- Kidney-Alone Transplantation in Diabetic Patients with End-Stage Renal Disease
- Parturition in Six Renal Allograft Recipients
- Limited Sampling Strategy for Estimating Area under the Concentration Curve for Mycophenolic Acid in Renal Transplant Recipients with Co-administration of Tacrolimus
- INTESTINAL ABSORPTION OF SEVERAL β-LACTAM ANTIBIOTICS. V.^ EFFECT OF AMINO β-LACTAM ANALOGUES AND DIPEPTIDES ON THE ABSORPTION OF AMINO β-LACTAM ANTIBIOTICS
- INTESTINAL ABSORPTION MECHANISMS OF SEVERAL ZWITTERIONIC β-LACTAM ANTIBIOTICS : ROLE OF BRUSH BORDER MEMBRANE AND BINDING TO F1 FRACTION
- Enterocolitis with pathogenic Escherichia coli infection in renal transplant recipients : Case reports
- Left Ventricular Regional Wall Motion in the Early Neonatal Period
- Peak Systolic Stress-Rate-Corrected Mean Velocity of Fiber Shortening in Preterm and Fullterm Infants
- SEVERAL FINDINGS ON THE MECHANISM OF GASTROINTESTINAL ABSORPTION OF QUATERNARY AMMONIUM COMPOUNDS
- INTERACTION OF TERTIARY AMINES AND QUATERNARY AMMONIUM COMPOUNDS WITH GASTROINTESTINAL MUCIN
- THE BEHAVIOR OF PENTAERYTHRITOL TETRANICOTINATE IN RAT GASTROINTESTINAL TRACT AS A PRODRUG
- TRANSPORT CHARACTERISTICS OF QUATERNARY AMMONIUM COMPOUNDS ACROSS RAT SMALL INTESTINAL BRUSH BORDER MEMBRANE
- INTESTINAL ABSORPTION OF SEVERAL β-LACTAM ANTIBIOTICS. IV. BINDING TO THE VARIOUS COMPONENTS IN THE INTESTINAL MUCOSA OF RAT AND ROLE IN ABSORPTION PROCESS
- INTESTINAL ABSORPTION OF SEVERAL β-LACTAM ANTIBIOTICS. III. COMPETITIVE INHIBITION BEHAVIOR AMONG ZWITTERIONIC β-LACTAM ANTIBIOTICS IN THE RAT INTESTINAL ABSORPTION
- Changes in Left Ventricular Diastolic Filling Patterns before and after the Closure of the Ductus Arteriosus in Very-Low-Birth Weight Infants
- Symptomatic Aortic Regurgitation after Blalock-Taussig Shunt in Tetralogy of Fallot with Bicuspid Aortic Valve
- Uptake of Methylchlorpromazine by Brush-Border Membrane Vesicles from Rat Small Intestine
- Squamous metaplasia mimicking papillary carcinoma in the upper urinary tract
- Squamous metaplasia mimicking papillary carcinoma in the upper urinary tract
- Altered Alpha-1-acid Glycoprotein Concentration and Free Fraction of Disopyramide in Patients with Heart Disease.
- Cyclosporin A therapy and drug monitoring by HPLC following renal transplantation.