A study of 5.ALPHA.-reductase in human fetal brain.
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概要
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To study 5α-reductase activity in the human fetal tissues, hypothalamus, cerebrum, skin, liver, kidney, small intestine, lung, adrenal and placenta of aborted fetuses at mid gestation were obtained and incubated with labeled Δ<SUP>4</SUP>-3-keto steroids under CO gas in the presence of excess NADPH.<BR>A higher conversion of progesterone to 5α-pregnanedione was observed in the hypothalamus and cerebrum than in other tissues studied. The major portion of 5α-reductase in the cerebrum was localized in 800×g precipitate (crude nuclear fraction). Androstenedione and progesterone were found preferred substrate for 5α-reductase to 17α-hydroxyprogesterone or testosterone. Km of 5α-reductase for progesterone and androstenedione were 1.0×10<SUP>-5</SUP> M and 9.0×10<SUP>-6</SUP> M, respectively. The enzyme activity for progesterone was inhibited by estrone and androstenedione but not by estriol.
- 社団法人 日本内分泌学会の論文
著者
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Yanaihara Takumi
Department Of Obstetrics And Gynecology School Of Medicine Showa University
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Nakayama Tetsuya
Department Of Obstetrics And Gynecology School Of Medicine Showa University
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Saitoh Hiroshi
Department Of Material Science And Technology Faculty Of Engineering Niigata University
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HIRATO KUMIKO
Department of Obstetrics and Gynecology, School of Medicine, Showa University
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SAITOH HIROSHI
Department of Obstetrics and Gynecology, School of Medicine, Showa University
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