Inhibition of fetal adrenal 21-hydroxylase by naturally occurring steroids.
スポンサーリンク
概要
- 論文の詳細を見る
Inhibitory effects of naturally occurring steroids on 21-hydroxylase activity were determined by measuring the initial conversion rate of 17-hydroxyprogesterone (17α-hydroxy-4-pregnene-3, 20-dione) to 11-deoxycortisol (17α, 21-dihydroxy-4-pregnene-3, 20-dione) in incubation experiments with the microsomal fraction (10, 000-105, 000 ×g precipitate) of the human fetal adrenal gland. The apparent Michaelis constant (Km) for conversion of 17-hydroxyprogesterone was 13.3×10<SUP>-6</SUP>M.<BR>Human fetal adrenal 21-hydroxylase was inhibited by some of the steroids produced in the feto-placental unit. The following steroids acted as competitive inhibitors of the reaction; progesterone (Ki=20.0×10<SUP>-6</SUP>M), 11-deoxycortisol (Ki=27.5×10<SUP>-6</SUP> M) and estradiol-17β(Ki=87.5×10<SUP>-6</SUP>M). The most potent inhibitor among the estrogens was estradiol-17β.
- 社団法人 日本内分泌学会の論文
著者
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Okinaga Shoichi
Department of Obstetrics & Gynecology, Teikyou University, School of Medicine, Ichihara Hospital,
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Yanaihara Takumi
Department Of Obstetrics And Gynecology School Of Medicine Showa University
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Shibusawa Haru
Department Of Chemistry Faculty Of Science Ochanomizu University
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Sekiba Kaoru
Department Of Obstetrics And Gynecology Okayama University Medical School
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Yoshida Nobutaka
Department Of Agrobioscience Graduate School Of Agricultural Science Kobe University
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SANO YUMIKO
Department of obstetrics and Gynecology, Teikyo University School of Medicine
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Arai Kiyoshi
Department Of Obstetrics And Gynecology Teikyo University School Of Medicine
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OKINAGA SHOICHI
Department of Obstetrics and Gymecology, Teikyo University School of Medicine
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SANO YUMIKO
Department of Obstetrics and Gymecology, Teikyo University School of Medicine
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SHIBUSAWA HARU
Department of Obstetrics and Gymecology, Teikyo University School of Medicine
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