Biosynthetic pathways for corticoids and androgen formation in human fetal adrenal tissue in vitro.
スポンサーリンク
概要
- 論文の詳細を見る
Eleven incubations of minced human fetal adrenal tissue from two fetuses at midtrimester of pregnancy terminated for socio-economic reasons, were performed for different periods of time with labelled pregnenolone, progesterone, 17α-hydroxyprogesterone and deoxycorticosterone (DOC). The order of magnitudes of enzyme activity when progesterone was used as a substrate and incubated with midterm fetal adrenals was 17α-hydroxylase, 21-hydroxylase and 16α-hydroxylase. The activity of 3β-hydroxysteroid dehydrogenase and Δ<SUB>5-4</SUB> isomerase was almost negligible as compared to other enzymic activities as mentioned above. Similar biosynthetic pathways for adrenal corticoids formation were observed in human fetal adrenals as reported in human adults and animals; once progesterone was converted into DOC, further 17α-hydroxylation did not take place.
- 社団法人 日本内分泌学会の論文
著者
-
Okinaga Shoichi
Department of Obstetrics & Gynecology, Teikyou University, School of Medicine, Ichihara Hospital,
-
Yanaihara Takumi
Department Of Obstetrics And Gynecology School Of Medicine Showa University
-
Shibusawa Haru
Department Of Chemistry Faculty Of Science Ochanomizu University
-
Sekiba Kaoru
Department Of Obstetrics And Gynecology Okayama University Medical School
-
Yoshida Nobutaka
Department Of Agrobioscience Graduate School Of Agricultural Science Kobe University
-
SANO YUMIKO
Department of obstetrics and Gynecology, Teikyo University School of Medicine
-
Arai Kiyoshi
Department Of Obstetrics And Gynecology Teikyo University School Of Medicine
-
OKINAGA SHOICHI
Department of Obstetrics and Gynecologly, Teikyo University School of Medicine
-
SEKIBA KAORU
Department of Obstetrics and Gynecology, Okayama University School of Medicine
-
Yanaihara Takumi
Department of Obstetrics and Gynecology, Showa University School of Medicine
-
SANO YUMIKO
Department of Obstetrics and Gymecology, Teikyo University School of Medicine
-
YOSHIDA NOBUTAKA
Department of Obstetrics and Gynecology, Okayama University School of Medicine
関連論文
- BIOSYNTHESIS OF STEROIDS BY HUMAN FETAL ADRENAL PERFUSED IN VITRO
- 366 Prediction of the occurrence of pregnancy induced hypertension(PIH) based on the changes in plasma PGI2 elicited by angiotensin II(A-II).
- Effects of fadrozole and leuprorelin acetate on aromatase activity and cell proliferation in a human breast cancer cell line (SK-BR-3)
- Inhibitory Effects of Catecholamines and Maternal Stress on Aromatase Activity in the Fetal Rat Brain
- Aromatase and Estrogen 2-Hydroxylase Activities of Human Placental Microsomes in Pregnancy-Induced Hypertension
- Effects of sintered apatite on bone regeneration in rabbits
- The Influence of Inflammatory Cytokines on Estrogen Production and Cell Proliferation in Human Breast Cancer Cells
- The Effect of Vaginal Delivery on the Pelvic Floor
- FETAL ACTIVITY DETERMlNATION AND NEOSYNEPHRlNE TEST FOR EVALUATION OF FETAL WELL-BElNG IN HIGH RISK PREGNANCIES
- PTHrP and PTH/PTHrP Receptor Expressions in Human Endometrium
- The Role of Parathyroid Hormone-Related Protein in Intra-Tracheal Fluid
- The Effect of Cytokines on Parathyroid Hormone-Related Protein (PTH-rP) Production in Human Amnion Cells
- Recombinant follicle-stimulating hormone (follitropin alfa) versus purified urinary follicle-stimulating hormone in a low-dose step-up regimen to induce ovulation in Japanese women with anti-estrogen-ineffective oligo- or anovulatory infertility : results
- Recombinant follicle-stimulating hormone (follitropin alfa) for ovulation induction in Japanese patients with anti-estrogen-ineffective oligo- or anovulatory infertility : results of a phase II dose-response study
- Periodate Oxidation for Sulfated Glycosaminoglycans, with Special Reference to the Position of Extra Sulfate Groups in Chondroitin Polysulfates, Chondroitin Sulfate D and Chondroitin Sulfate K
- 3β-Hydroxysteroid Dehydrogenase Activity in Human Osteoblast-Like Cells
- A Study of γ-Aminobutyric Acid (GABA) in Amniotic Fluid
- Treatment of a Crown Malformation in a Lower Left Permanent Central Incisor Tooth Derived from Earlier Traumatic Injuries to a Primary Tooth Based on Diagnosis using 3DX^(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayam
- THE EFFECT OF AN ACUTE STRESS IN LATE PREGNANCY ON HYPOTHALAMIC CATECHOLAMINES OF THE RAT FETUS
- Application of Forward Dispersion Relation to Kaon Carbon Scattering
- Sodium Fluoride (NaF) Releases the Two-Cell Block in Mouse Embryos
- Severe 5-fluorouracil-induced toxicity due to decreased dihydropyrimidine dehydrogenase activity: report of a patient survival and urinary pyrimidine and dihydropyrimidine levels
- Molecular Cloning and Sequence Analysis of Two Distinct Halotolerant Extracellular Proteases from Bacillus subtilis FP-133
- Intravenous Leiomyomatosis : Three Cases-Reports
- PATHWAY OF THE FORMATION OF ESTRIOL IN THE FETOPLACENTAL UNIT
- FORMATION OF ESTROGENS IN THE FETO-PLACENTAL COMPARTMENTS
- 16α HYDROXYLATION OF DEHYDROEPIANDROSTERONE BY HUMAN FETAL TISSUES
- BIOGENESIS OF ESTROGENS BY THE PERFUSED HUMAN OVARY (I) CONVERSION OF PROGESTERONE-14C AND ANDROST-4-ENE-3, 17-DIONE-14C TO ESTRADIOL-17β
- BIOSYNTHESIS OF ESTROGENS IN IN VITRO PERFUSION OF THE HUMAN PLACENTA
- THE FORMATION OF ESTRIOL FROM ESTRADIOL-17β BY THE HUMAN FETAL ADRENAL TISSUE
- ESTIMATION OF GESTOSIS OF PREGNANCY (EPHGESTOSIS), RELATIONSHIP BETWEEN FETAL DEVELOPMENT AND GESTOSIS INDEX
- IMMUNOHISTOCHEMICAL APPROACH FOR DETECTION OF THE PROLIFERATING CELLS IN UTERINE CANCER
- CRYOSURGERY FOR GYNECOLOGIC CANCER
- Stainability of steroid hormones in tissue using different fixatives
- Metabolic Fate of 3H-Testosterone Administered into the Fetoplacental Compartments
- The Effect of Ovarian Steroid Feedback upon Radioimmunoreactive Luteinizing Hormone Releasing Hormone in the Hypothalamus
- Possibility of application of calcium carbonate in pulpotomy of rat molars
- A Radioimmunoassay of Serum 16α-Hydroxypregnenolone With Specific Antiserum
- The formaldehyde inspiration by the child patient, dentist, and dental assistant during formocresol pulpotomy
- Biosynthetic pathways for corticoids and androgen formation in human fetal adrenal tissue in vitro.
- Inhibition of fetal adrenal 21-hydroxylase by naturally occurring steroids.
- A study of 5.ALPHA.-reductase in human fetal brain.