BIOGENESIS OF ESTROGENS BY THE PERFUSED HUMAN OVARY (I) CONVERSION OF PROGESTERONE-<SUP>14</SUP>C AND ANDROST-4-ENE-3, 17-DIONE-<SUP>14</SUP>C TO ESTRADIOL-17β
スポンサーリンク
概要
- 論文の詳細を見る
Human ovaries were obtained from two normally menstruating women who had received PMS and HCG before the operation and biosynthesis of estrogen was investigated with a perfusion technique. As substrates, progesterone-4-<SUP>14</SUP>C and androstenedione-4-<SUP>14</SUP>C were added into the perfusate. The phenolic fraction of the extract of the perfusate was purified by gradient elution partition chromatography on a Celite column and paper chromatography. Throughout these purification steps, the radioactive metabolite in the estradiol fraction behaved exactly as the carrier estradiol. The conversion rate of progesterone into estradiol was 1.5% and that of androstenedione was 4.7%. The advantages of a perfusion experiment for the study of biosynthesis and metabolism of estrogen were discussed.
- 社団法人 日本内分泌学会の論文
著者
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SATOH Kazuo
Department of Electronic Engineering, Faculty of Engineering, Osaka University
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Yanaihara Takumi
Department Of Obstetrics And Gynecology School Of Medicine Showa University
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Nakayama Tetsuya
Department Of Obstetrics And Gynecology School Of Medicine Showa University
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Fujita Yoshihisa
Department of Chemistry, Biology and Marine Science, University of the Ryukyus
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Arai Kiyoshi
Department Of Pediatric Dentistry Nihon University Graduate School Of Dentistry At Matsudo
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NAGATOMI KEIJI
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
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TABEI TORU
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
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Fujita Yoshihisa
Department Of Anesthesiology & Intensive Care Medicine Kawasaki Medical School
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Arai Kiyoshi
Department Of Obstetrics And Gynecology Teikyo University School Of Medicine
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SATOH KAZUO
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
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