THE EFFECT OF AN ACUTE STRESS IN LATE PREGNANCY ON HYPOTHALAMIC CATECHOLAMINES OF THE RAT FETUS
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概要
- 論文の詳細を見る
胎生後期の慢性ストレスはラット胎仔の周生期のアンドロゲン環境に影響を与え, 雌雄で中枢の性分化を障害することが知られるが, その発生機序に対する胎仔中枢の関与はいまだ明らかではない. 我々は, 母体ストレス下の胎仔神経内分泌系の変化を知る目的で雌雄胎仔視床下部カテコールアミン含量を測定した. 妊娠20日のウィスター系ラットに180分までの拘束ストレスを負荷, 母仔の血液, 視床下部を採取し, 血中 corticosterone(B)はRIA, dopamine (DA), norepinephrine (NE), epinephrine (E)含量は radioenzymeassayにて測定した. 妊娠20日の急性ストレス負荷時, 母仔血中Bは60分で頂値を示した. 母ラットの視床下部DAはストレスで有意な変化を示さず, NEはストレス前値 (328±33pg/mgT)に対し120分 (219±11pg/mgT), 180分 (204±11pg/mgT), Eはストレス前値 (28±3pg/mgT)に対し180分 (12±3pg/mgT)で有意に低下した. 胎仔視床下部では, 雌雄ともにDAは減少傾向がみられ, Eで変動は認めなかつたが, NEはストレス前値 雄 : 140±11, 雌 : 22±13pg/mgT)に比し120分(雄 : 79±10, 雌 : 68±9pg/mgT), 180分(雄 : 73±8, 雌 : 70±5pg/mgT)で有意に減少した. 以上の成績から, 妊娠後期の母体ストレスはアンドロゲン依存性分化に重要な役割を担う胎仔視床下部NE含量を低下させることを示した.
- 1991-07-01
著者
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Okinaga Shoichi
Department of Obstetrics & Gynecology, Teikyou University, School of Medicine, Ichihara Hospital,
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MURASE Takayuki
Department of Pathology, Nagoya City University Graduate School of Medical Sciences
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Murase Takayuki
Department Of Obstetrics And Gynecology Teikyo University School Of Medicine
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ARAI Kiyoshi
Department of Pediatric Dentistry, Nihon University Graduate School of Dentistry at Matsudo
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Arai Kiyoshi
Department Of Pediatric Dentistry Nihon University Graduate School Of Dentistry At Matsudo
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OHKAWA Tomi
Department of Obstetrics and Gynecology, Teikyo University School of Medicine
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TAKESHITA Shigeki
Department of Obstetrics and Gynecology, Teikyo University School of Medicine
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Ohkawa Tomi
Department Of Obstetrics And Gynecology Teikyo University School Of Medicine
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Okinaga Shoichi
Department Of Obstetrics And Gynecology Teikyo University School Of Medicine
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Takeshita Shigeki
Department Of Obstetrics And Gynecology Teikyo University School Of Medicine
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Arai Kiyoshi
Department Of Obstetrics And Gynecology Teikyo University School Of Medicine
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