Cytokine Production by Peripheral Blood Mononuclear Cells and Metabolic Turnover of Bone During Pregnancy.

スポンサーリンク

概要

• 論文の詳細を見る

• We studied the dynamic turnover of bone by measuring metabolic markers in 6 healthy pregnant women, aged 23-28. Resorption markers, tartrate-resistant acid phosphatase and deoxypyridinoline, increased in the last trimester and after partrition decreased until puerperium day 30. The serum level of intact osteocalcin, a formation marker, exhibited a slight decrease during pregnancy and increased following childbirth. In the last trimester, the peripheral monocyte secreted much amount of interleukin (IL)-1 and tumor necrosis factor (TNF)-α, potent stimulants of osteoclast, in parallel with the resorption markers. Estrogen has the bone sparing effect by inhibiting cytokine secretion in the bone microenvironment and peripheral mononuclear cell. Biomarker changes, however, disclosed uncoupling of bone with high resorption and low formation in the last trimester with a higher estrogen level than any other period of life, which might be mediated by a high amount of IL-1 and TNF-α through stimulating osteoclast activity.

• 日本学士院の論文

著者

• SATOH Kazuo

  Department of Electronic Engineering, Faculty of Engineering, Osaka University

• Kushida Kazuhiro

  Department Of Orthopaedic Surgery Hamamatsu University School Of Medicine

• Ooishi Tsuyoshi

  Department Of Infectious Disease Tokyo Medical University Kasumigaura Hospital

• Fukuoka Hideoki

  Department Of Developmental Medical Science Division Of International Health Tokyo University Gradua

• Inoue Tetsuo

  Department Of Anesthesia Chiba Hokusoh Hospital Nippon Medical School

• HIGURASHI Makoto

  Department of Maternal and Child Health, Faculty of Medicine, University of Tokyo

• HIGURASHI Makoto

  Department of Health Sciences, Medical University of Yamanashi

• KIRIYAMA Megumi

  Department of Maternal and Child Health, Faculty of Medicine, University of Tokyo

• HONDA Toshie

  Department of Obstetrics and Gynecology, Nihon University

• KUSHIDA Kazuhiro

  Department of Orthopedic Surgery, Hamamatsu Medical School

• OOISHI Tsuyoshi

  Department of Orthopedic Surgery, Hamamatsu Medical School

関連論文

• Report on the Japanese Orthopaedic Association's 3-year project observing hip fractures at fixed-point hospitals
• Anomalous Phase Sequence in Binary Mixture of 3MC2PCPOPB and TFMHPOBC ( FERROELECTRIC MATERIALS AND THEIR APPLICATIONS)
• Localization of Serum Proteins in the Embryo
• Age and menopause-related changes in phalangeal bone density of Japanese women, measured by a digital image processing method
• Age and menopause-related changes in phalangeal bone density of Japanese women, measured by a digital image processing method
• The effects of nandrolone decanoate on bone mass and metabolism in ovariectomized rats with osteopenia
• Estimation of the effects of prednisolone on bone metabolism in rats by biochemical markers
• Investigation of the performance of ELISA for N-terminal midfragment of osteocalcin
• Circadian rhythm of the urinary crosslinks pyridinoline and deoxypyridinoline in normal human and involutional osteoporosis
• Urinary Excretion of D-Serine in Human : Comparison of Different Ages and Species
• Analysis of bone mineral density in urolithiasis patients
• A comparison of incidences of vertebral fracture in Japanese patients with involutional osteoporosis treated with risedronate and etidronate : a randomized, double-masked trial
• Alendronate reduced vertebral fracture risk in postmenopausal Japanese women with osteoporosis : a 3-year follow-up study
• A Placebo-Controlled, Single-Blind Study to Determine the Appropriate Alendronate Dosage in Postmenopausal Japanese Patients with Osteopotosis
• Effect of elcatonin on involutional osteoporosis
• Guidelines on the use of biochemical markers of bone turnover in osteoporosis (2001)
• Changes in Purine Metabolism and Production of Oxygen Free Radicals by Intermittent Partial Umbilical Cord Occlusion in Chronically Instrumented Fetal Lambs
• Efficacy and tolerability of once-weekly administration of 17.5mg risedronate in Japanese patients with involutional osteoporosis : a comparison with 2.5-mg once-daily dosage regimen
• Diagnostic criteria of primary osteoporosis
• Effects of Static Magnetic Fields on the Induction of Sister Chromatid Exchange in Human Lymphocytes in vitro
• The Effect of Ageing on Mutagen-Induced SCE in Mouse Spleen Lymphocytes
• The Effect of Ageing on Cell Cycle Kinetics in Mouse Spleen Lymphocytes
• X-ray induced Sister Chromatid Exchange and Chromosomal Aberrations in the Lymphocytes from the Patients with Neurofibromatosis
• Prolonged Swimming Exercise Training Induce Hypophosphatemic Osteopenia in Stroke-Prone Spontaneously Hypertensive Rats(SHRSP)
• Hip fracture patients without vertebral fracture have a preferential osteopenia in the proximal femur
• Optically Detected Cyclotron Resonance in CdTe
• Reduction of bone mineral density in rheumatoid arthritis: A longitudinal study
• Sister Chromatid Exchange (SCE) Frequency in Human and Simian Lymphoid Cell Lines Infected with Simian Retroviruses Closely Related to Human T-cell Leukemia Virus Type-1
• Prostaglandin F2α Metabofites in Plasma and Urine in Relation to Peripheral Plasma Levels of Progesterone and Estradiof-17β in the Rat During Pregnancy and Parturition
• Health Care Program for Patients with Down Syndrome
• Emerging and entraining patterns of the sleep-wake rhythm in preterm and term infants
• Improvement of Preservation Method for Ammonia-Oxidizing Bacteria by Freeze-Drying(Soil Biology)
• Two Kinds of Ammonia-Oxidizing Bacteria Isolated from Biologically Deodorizing Plants in Cold District(ENVIRONMENTAL BIOTECHNOLOGY)
• Effects of rapid inhalation induction with sevoflurane-oxygen anesthesia on epidural pressuer in humans
• Prevalence of vertebral fractures in a population-based sample in Japan
• Effects of 2 Years' Treatment of Osteoporosis with 1α-Hydroxy Vitamin D3 on Bone Mineral Density and Incidence of Fracture : A Placebo-Controlled, Double-Blind Prospective Study
• A case of femoral neck fracture in a patient with severe testosterone deficiency
• Pachygyria in a girl with microcephalic osteodysplastic primordial short stature type II
• Measurement of vertebral body dimensions of the thoracic and lumbar spines of 242 healthy women
• Case of cutaneous Scedosporium apiospermum infection successfully treated with voriconazole
• The protein throsin kinase Fyn activates transcriprion from the HIV promoter via activation of NFκB-like DNA-binding proteins
• PATHWAY OF THE FORMATION OF ESTRIOL IN THE FETOPLACENTAL UNIT
• FORMATION OF ESTROGENS IN THE FETO-PLACENTAL COMPARTMENTS
• 16α HYDROXYLATION OF DEHYDROEPIANDROSTERONE BY HUMAN FETAL TISSUES
• BIOGENESIS OF ESTROGENS BY THE PERFUSED HUMAN OVARY (I) CONVERSION OF PROGESTERONE-14C AND ANDROST-4-ENE-3, 17-DIONE-14C TO ESTRADIOL-17β
• BIOSYNTHESIS OF ESTROGENS IN IN VITRO PERFUSION OF THE HUMAN PLACENTA
• THE FORMATION OF ESTRIOL FROM ESTRADIOL-17β BY THE HUMAN FETAL ADRENAL TISSUE
• The Possibility of Clinical Application of the Thromboxane A_2 Synthase Inhibitor, Ozagrel, for the Treatment and Prevention of Preeclampsia : A Preliminary Report
• Peritoneal and Peripheral B-1-Cell Populations in Patients with Endometriosis
• Risk factors for small for gestational age
• Increase in low-birth-weight infants in Japan and associated risk factors, 1980-2000
• Prostaglandin F2α and E1 in Plasma and Amniotic Fluid During Human Pregnancy and Labor
• Biosynthesis of Prostaglandin in Human Decidua, Amnion, Chorion and Villi
• Changes in hemodynamic variables and catecholamine levels after rapid increase in sevoflurane or isoflurane concentration with or without nitrous oxide under endotracheal intubation
• COPPER AS AN ANTIFERTILITY AGENT IN INTRAUTERlNE DEVICES
• Application of the Truview EV02 optical laryngoscope to patients with cervical spinal disease
• Sensitization to Bjerkandera adusta Enhances Severity of Cough Symptom in Patients with Fungus-Associated Chronic Cough(FACC)
• Clinical aspects of involutional osteoporosis
• Radioimmunoassay of Serum Parathyroid Hormone in Postmenopausal Osteoporosis
• Numerical Conformal Mappings of the Domain Whose Outer Boundary Is a Unit Circle
• The degree of osteoporosis in patients with vertebral fracture and patients with hip fracture: Relationship to incidence of vertebral fracture
• New Charge Simulation Method for Numerical Conformal Mapping of Ring Domains
• Optically Detected Cyclotron Resonance in CdTe
• Safety of measles vaccination to the patients with down syndrome on the chromosomal level.
• Effects of mitomycin C on the frequency of sister chromatid exchanges in lymphocytes cultured from patients with down syndrome.
• Y chromatin and estrogen.
• Cytokine Production by Peripheral Blood Mononuclear Cells and Metabolic Turnover of Bone During Pregnancy.
• Frequencies of sister chromatid exchanges in cells from patients with neurofibromatosis induced by mitomycin-C.
• Vinyl acetate-induced sister chromatid exchanges in murine bone marrow cells.
• Spontaneous and mitomycin-C induced sister chromatid exchanges in cells from patients with tuberous sclerosis.
• Spontaneous and mitomycin-C induced the sister chromatid exchanges in lymphocytes from patients with cri du chat syndrome.
• Derivation of Path of Contact and Tooth Flank Modification by Minimizing Transmission Error on Face Gear

もっと見る 閉じる

スポンサーリンク