Prolonged Swimming Exercise Training Induce Hypophosphatemic Osteopenia in Stroke-Prone Spontaneously Hypertensive Rats(SHRSP)
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概要
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Stroke-prone spontaneously hypertensive rats(SHRSP)induce spontaneous osteoporosis. To dlucidate the specific characteristics of bone metabolism, the SHRSP was compared with age matched Wistar-Kyoto(WKY)rats. We investigated the effects of prolonged swimming exercise training on bone mineral density(BMD)and metabolism in the SHRSP. Seven-week-old male SHRSP and WKY were divided into three groups; the sedentary control WKY group(n=6, WKY), the sedentary control SHRSP group(n=6, SP)and the swimming exercise training SHRSP group(n=6, SWIM)(in pool with 60 min./day, 5 day/week for 12 weeks). The femoral BMD, bone mineral content(BMC), strength, Ca and P contents(%)of SHRSP were approximately 17, 27, 25, 20 and 9%, respectively, lower than that of WKY(p<0.001). Serum alkaline phosphatase(AlP)had not changed between both of SP and WKY, but tartrate-resistant acid phosphatase(TrAcP)of SP approximately 3-fold higher than that of WKY(p<0.05). Both serum calcium(Ca)and intact parathyroid hormone(i-PTH)were similar between SP and WKY. However, serum phosphate(P)of SP was approximately 18% lower than that of WKY(N.S.). These results suggested that SHRSP induces osteopenia by the bone turnover of the promoted osteoclast activity with disturbed phosphate homeostasis. On the other hand, the femoral BMD and strength were approximately 7% and 20%, respectively, decreased in the SWIM(p<0.001), and femoral bone Ca and P contents(%)were also approximately 11% and 14%, respectively, lower than that of SP(p<0.001). There were no significant difference between SWIM and SP on serum Ca, but serum P of SWIM was significantly lower than that of SP(p<0.05). These results suggested that the prolonged swimming exercise training in the SHRSP induces more cruelly hypophosphatemia, and leading to osteopenia eventually. We conclude that SHRSP induces osteopenia with disturbance of phosphate homeostasis, and the prolonged swimming exercise in the SHRSP might deteriorate hypophosphatemia and osteopenia.
- 日本生理人類学会の論文
著者
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Igawa Shoji
Department of Health Care, Nippon Sport Science University
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Igawa S
Nippon Sport Sci. Univ. Yokohama Jpn
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Igawa Shoji
Department Of Health Administration Nippon College Of Physical Education
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Kim Chang-Sun
Department of Community Sports and Recreation, Kyongju University
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Kim Chang-sun
Department Of Community Sports And Recreation Kyongju University
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Oh T‐w
Waseda Univ. Tokorozawa Jpn
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Oh Tae-woong
Department Of Sports Sciences School Of Human Sciences Waseda University
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YANG Chu-Ya
Department of Sports Sciences, Waseda University School of Human Sciences
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NAKAJIMA Daito
Department of Sports Sciences, Waseda University School of Human Sciences
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OHTA Fukio
Department of Sports Sciences, Waseda University School of Human Sciences
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Miyazaki Masami
Department of Sports Sciences, School of Human Sciences, Waseda University
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Fukuoka Hideoki
Department of Developmental Medical Sciences, The University of Tokyo
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Ohta Fukio
Department Of Sports Sciences Waseda University School Of Human Sciences
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Ohta Fukio
Department Of Sports Sciences School Of Human Sciences Waseda University
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Yang Chu-ya
Department Of Sports Sciences Waseda University School Of Human Sciences
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Nakajima Daito
Department Of Sports Sciences Waseda University School Of Human Sciences
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Miyazaki Masami
Department Of Human Informatics And Cognitive Sciences Waseda University
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Miyazaki Masami
Department Of Sports Sciences School Of Human Sciences Waseda University
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Fukuoka H
Department Of Developmental Medical Sciences The University Of Tokyo
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Fukuoka Hideoki
Department Of Developmental Medical Science Division Of International Health Tokyo University Gradua
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