Effects of Habitual Chitosan Intake on Bone Mass, Bone-Related Metabolic Markers and Duodenum CaBP D9K mRNA in Ovariectomized SHRSP Rats.
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概要
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We have demonstrated that the habitual intake of chitosan can decrease bone mass in ovariectomized (OVX) SHRSP rats fed a low-Ca diet (0.1%). In the present study, we examined both the etiology of bone loss induced by dietary chitosan and the preventive effect of vitamin C supplementation. Rats were OVX and maintained on one of the following diets for 6 wk: 10% cellulose (CE), 10% chitosan (CH) or 10% chitosan with sodium ascorbate (CHVC). CH caused a significant reduction in bone mineral density (BMD) and stiffness in femurs and the fourth lumbar vertebrae (L4). There was no significant difference in intestinal Ca absorption between CH and CE, whereas CH intake significantly reduced intestinal P absorption. The bone loss in CH rats was accompanied with an increase in urinary Ca excretion and a decrease in serum Ca as well as a significant increment in serum PTH and 1, 25(OH)2D3. The vitamin D receptor and calcium binding protein D9K mRNAs were also significantly increased in the duodenum of CH rats. Vitamin C supplementation to CH caused an increase in the Ca and P contents of femurs as well as BMD of the L4, with a decrease in urinary Ca excretion. These results indicate that dietary chitosan with low Ca intake possibly induces the loss of bone mass by enhancing urinary Ca excretion rather than by inhibiting Ca absorption, and that vitamin C supplementation could prevent bone loss caused by chitosan through the increment of retained Ca followed by suppression of urinary Ca excretion.
- 財団法人 学会誌刊行センターの論文
著者
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Igawa Shoji
Department Of Health Administration Nippon College Of Physical Education
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Kim Chang-sun
Department Of Community Sports And Recreation Kyongju University
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Oh Tae-woong
Department Of Sports Sciences School Of Human Sciences Waseda University
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Naka Tatsuki
Department Of Health Care Nippon Sport Science University
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Ohta Fukio
Department Of Sports Sciences School Of Human Sciences Waseda University
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Yang Chu-ya
Department Of Sports Sciences Waseda University School Of Human Sciences
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Maeda Atsuko
Department Of Sports Sciences Waseda University School Of Human Sciences
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Nakajima Daito
Department Of Sports Sciences Waseda University School Of Human Sciences
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Oh Tae-Woong
Department of Sports Sciences, Waseda University School of Human Sciences
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Naka Tatsuki
Department of Health Care, Nippon Sport Science University
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